TY - JOUR
T1 - Antibody‐mediated peripheral neuropathies associated with ARC and AIDS
T2 - Successful treatment with plasmapheresis
AU - Kiprov, Dobri
AU - Pfaeffl, Wolfgang
AU - Parry, Gareth
AU - Lippert, Randolph
AU - Lang, William
AU - Miller, Robert
PY - 1988
Y1 - 1988
N2 - Peripheral neuropathy is increasingly recognized in patients with AIDS as well as AIDS‐related complex (ARC). Thirty homosexual men with polyneuropathy were evaluated in this study. Twenty‐one had ARC and nine had AIDS. We observed three distinct clinical syndromes: distal sensorimotor polyneuropathy, chronic inflammatory demyelinating polyrediculoneuropathy (CIDP), and mononeuropathy multiplex. Circulating antibodies to peripheral nerve tissues were found in all patients. In six patients, treatment with plasma exchange was undertaken because of severe, progressive weakness. Four patients with clinical, electoophys‐iologic, and histologic evidence of CIDP improved with plasma exchange, three regaining normal function. These results suggest that the peripheral neuropathy associated with ARC and AIDS is immunotogically mediated and that plasma exchange is an effective treatment in a subgroup of patients with this disorder.
AB - Peripheral neuropathy is increasingly recognized in patients with AIDS as well as AIDS‐related complex (ARC). Thirty homosexual men with polyneuropathy were evaluated in this study. Twenty‐one had ARC and nine had AIDS. We observed three distinct clinical syndromes: distal sensorimotor polyneuropathy, chronic inflammatory demyelinating polyrediculoneuropathy (CIDP), and mononeuropathy multiplex. Circulating antibodies to peripheral nerve tissues were found in all patients. In six patients, treatment with plasma exchange was undertaken because of severe, progressive weakness. Four patients with clinical, electoophys‐iologic, and histologic evidence of CIDP improved with plasma exchange, three regaining normal function. These results suggest that the peripheral neuropathy associated with ARC and AIDS is immunotogically mediated and that plasma exchange is an effective treatment in a subgroup of patients with this disorder.
KW - HIV
KW - immunologic mechanism
KW - polyneuropathy
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U2 - 10.1002/jca.2920040103
DO - 10.1002/jca.2920040103
M3 - Article
C2 - 3391987
AN - SCOPUS:0023942242
SN - 0733-2459
VL - 4
SP - 3
EP - 7
JO - Journal of clinical apheresis
JF - Journal of clinical apheresis
IS - 1
ER -