Abstract
Although the presentation of peptide - major histocompatibility complex class II (pMHC class II) complexes to CD4 T cells has been studied extensively in vitro, knowledge of this process in vivo is limited. Unlike the in vitro situation, antigen presentation in vivo takes place within a complex microenvironment in which the movements of antigens, antigen-presenting cells (APCs) and T cells are governed by anatomic constraints. Here we review developments in the areas of lymph node architecture, APC subsets and T cell activation that have shed light on how antigen presentation occurs in the lymph nodes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 733-739 |
| Number of pages | 7 |
| Journal | Nature immunology |
| Volume | 4 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2003 |
Bibliographical note
Funding Information:We thank T. Leonard for help with the animation. Supported by grants from the National Institutes of Health and the Irvington Institute of Immunological Research.
