Antiinflammatory effects of murine malignant cells

R. M. Fauve, B. Hevin, H. Jacob, J. A. Gaillard, F. Jacob

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Development of teratocarcinoma does not impair immunization of mice against Listeria monocytogenes. Endotoxin injection a short time before tumor cell inoculation allows the growth of teratocarcinoma in nonsyngenic mice despite immune stimulation. In contrast with this absence of impaired systematic immunity, teratocarcinoma cells were found to repulse macrophages in vitro. This effect on macrophages was also found with three other malignant cells and with trophoblast cells. In vivo, teratocarcinoma cells were found to impair local inflammation. These cells and other malignant cells are able to produce a compound(s) of mol wt between 10 3 and 10 4, which prevents inflammatory reaction. These results suggest that mouse teratocarcinomas and other tumors by pass the host immunological system of surveillance by at least two mechanisms: a direct toxic effect on macrophages and the release of an inhibitor of inflammation. The possible relations between these properties of malignant cells and physiological functions of trophoblast are discussed.

Original languageEnglish (US)
Pages (from-to)4052-4056
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume71
Issue number10
DOIs
StatePublished - 1974

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