Antineoplastic agents. 570. isolation and structure elucidation of bacillistatins 1 and 2 from a marine bacillus silvestris

George R. Pettit, John C. Knight, Delbert L. Herald, Robin K. Pettit, Fiona Hogan, Venugopal J.R.V. Mukku, John S. Hamblin, Michael J. Dodson, Jean Charles Chapuis

    Research output: Contribution to journalArticlepeer-review

    25 Scopus citations

    Abstract

    Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.

    Original languageEnglish (US)
    Pages (from-to)366-371
    Number of pages6
    JournalJournal of Natural Products
    Volume72
    Issue number3
    DOIs
    StatePublished - Mar 27 2009

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