Abstract
Two new cyclodepsipeptides designated bacillistatins 1 (1)and2(2) have been isolated from cultures of a sample of Bacillus silvestris that was obtained from a Pacific Ocean (southern Chile) crab. Each 12-unit cyclodepsipeptide strongly inhibited growth of a human cancer cell line panel, with GI 50's of 10 -4-10 -5 μg/mL, and each compound was active against antibiotic-resistant Streptococcus pneumoniae. The structures were elucidated by a combination of X-ray diffraction and mass and 2D NMR spectroscopic analyses, together with chemical degradation.
Original language | English (US) |
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Pages (from-to) | 366-371 |
Number of pages | 6 |
Journal | Journal of Natural Products |
Volume | 72 |
Issue number | 3 |
DOIs | |
State | Published - Mar 27 2009 |