Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX

Virginia M. Goett; Alice A. Larson

doi:10.1016/0006-8993(94)90939-3

Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX

Virginia M. Goett, Alice A. Larson

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Excitatory amino acid receptors have been implicated in mediating pain. 3-((±)-2-Carboxypiperazin4-yl)-propyl-1-phosphonic acid (CPP), a competitive N-methyl-d-aspartate (NMDA) antagonist and MK-801, a phencyclidine (PCP) ligand and non-competitive NMDA antagonist, were injected intrathecally in mice alone or in combination with 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist. When tested in the formalin model of pain, antinociception following CPP plus DNQX was greater than that after MK-801 plus DNQX in both the acute and tonic phases. These dissimilarities are not consistent with activity of CPP and MK-801 at the same sites in the spinal cord.

Original language	English (US)
Pages (from-to)	334-338
Number of pages	5
Journal	Brain Research
Volume	642
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(94)90939-3
State	Published - Apr 11 1994

Keywords

3-((±)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
6,7-Dinitroquinoxaline-2,3-dione
Formalin
MK-801
N-Methyl-d-aspartate
Non-N-methyl-d-aspartate
PCP
Pain

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Goett, V. M., & Larson, A. A. (1994). Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX. Brain Research, 642(1-2), 334-338. https://doi.org/10.1016/0006-8993(94)90939-3

Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX. / Goett, Virginia M.; Larson, Alice A.
In: Brain Research, Vol. 642, No. 1-2, 11.04.1994, p. 334-338.

Research output: Contribution to journal › Article › peer-review

Goett, VM & Larson, AA 1994, 'Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX', Brain Research, vol. 642, no. 1-2, pp. 334-338. https://doi.org/10.1016/0006-8993(94)90939-3

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abstract = "Excitatory amino acid receptors have been implicated in mediating pain. 3-((±)-2-Carboxypiperazin4-yl)-propyl-1-phosphonic acid (CPP), a competitive N-methyl-d-aspartate (NMDA) antagonist and MK-801, a phencyclidine (PCP) ligand and non-competitive NMDA antagonist, were injected intrathecally in mice alone or in combination with 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist. When tested in the formalin model of pain, antinociception following CPP plus DNQX was greater than that after MK-801 plus DNQX in both the acute and tonic phases. These dissimilarities are not consistent with activity of CPP and MK-801 at the same sites in the spinal cord.",

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Antinociception induced by 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP), an N-methyl-d-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 plus DNQX

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