TY - JOUR
T1 - Antioxidant signaling in skeletal muscle
T2 - A brief review
AU - Ji, Li Li
PY - 2007/7/1
Y1 - 2007/7/1
N2 - Generation of reactive oxygen species (ROS) is a ubiquitous biological phenomenon in eukaryotic cell life. During the past two decades, much attention has been paid to the detrimental effects of ROS such as oxidative stress, pathogenesis and aging. However, there is now increasing evidence and recognition that ROS are not merely damaging agents inflicting random destruction to the cell structure and function, but useful signaling molecules to regulate growth, differentiation, proliferation, and apoptosis, at least within the physiological concentration. In skeletal muscle contractile activity has been shown to upregulate antioxidant defense systems and ROS has been postulated to be essential in this adaptation. Available research data suggest that nuclear factor (NF)κB and mitogen-activated protein kinase (MAPK) play a critical role in the relay of oxidative stress signals to gene expression apparatus in the myocytes under a variety of physiological and pathological conditions. This mini-review will discuss the main mechanisms and gene targets for these antioxidant signaling pathways during exercise, inflammation and aging.
AB - Generation of reactive oxygen species (ROS) is a ubiquitous biological phenomenon in eukaryotic cell life. During the past two decades, much attention has been paid to the detrimental effects of ROS such as oxidative stress, pathogenesis and aging. However, there is now increasing evidence and recognition that ROS are not merely damaging agents inflicting random destruction to the cell structure and function, but useful signaling molecules to regulate growth, differentiation, proliferation, and apoptosis, at least within the physiological concentration. In skeletal muscle contractile activity has been shown to upregulate antioxidant defense systems and ROS has been postulated to be essential in this adaptation. Available research data suggest that nuclear factor (NF)κB and mitogen-activated protein kinase (MAPK) play a critical role in the relay of oxidative stress signals to gene expression apparatus in the myocytes under a variety of physiological and pathological conditions. This mini-review will discuss the main mechanisms and gene targets for these antioxidant signaling pathways during exercise, inflammation and aging.
KW - Antioxidant
KW - Exercise
KW - MAPK
KW - NFκB
KW - Reactive oxygen species
KW - Signaling
UR - http://www.scopus.com/inward/record.url?scp=34248573796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248573796&partnerID=8YFLogxK
U2 - 10.1016/j.exger.2007.03.002
DO - 10.1016/j.exger.2007.03.002
M3 - Short survey
C2 - 17467943
AN - SCOPUS:34248573796
SN - 0531-5565
VL - 42
SP - 582
EP - 593
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 7
ER -