Abstract
Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.
Original language | English (US) |
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Pages (from-to) | 164-167 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 818 |
Issue number | 1 |
DOIs | |
State | Published - Feb 6 1999 |
Bibliographical note
Funding Information:This work was supported by a grant from the Max Baer Heart Fund, Dakota Aerie of the Fraternal Order of Eagles.
Keywords
- Adrenomedullin
- Antisense
- Salt appetite