Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.
Bibliographical noteFunding Information:
This work was supported by a grant from the Max Baer Heart Fund, Dakota Aerie of the Fraternal Order of Eagles.
Copyright 2007 Elsevier B.V., All rights reserved.
- Salt appetite