APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients

Dale S. Gregerson, Hidetoshi Kawashima

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

T cell adoptive transfer models of autoimmune disease have been used in conjunction with radiation/bone marrow chimeras to define the minimal requirements for antigen (Ag) recognition. In models with central nervous system Ags, major histocompatibility complex (MHC) class II compatibility achieved by grafting F1 bone marrow into parental recipients was reported to be necessary and sufficient for transfer of CD4 T cell-mediated experimental autoimmune encephalomyelitis. Bone marrow-derived, perivascular microglia are now widely regarded to play a critical role in the expression of experimental autoimmume diseases of the nervous system. Similar results might be expected in the experimental autoimmune uveoretinitis model, as retina is an extension of the brain. Using an allogeneic Ag-presenting cell (APC) adoptive transfer strategy, it was found that resident APC were not essential and that their replacement with MHC-compatible cells by bone marrow-grafting techniques was not necessary. Instead, APC were recruited from the circulation.

Original languageEnglish (US)
Pages (from-to)383-387
Number of pages5
JournalJournal of Leukocyte Biology
Volume76
Issue number2
DOIs
StatePublished - Aug 2004

Keywords

  • Antigen presentation
  • Arrestin
  • Autoimmunity
  • T cells
  • Uveoretinitis

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