Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells

Medicine & Life Sciences

• Acrocephalosyndactylia 100%
• Gene Expression 40%
• Mutation 37%
• Periosteum 15%
• Genes 14%
• Transcriptome 11%
• Down-Regulation 8%
• Gain of Function Mutation 8%
• Cell Proliferation 8%
• Craniosynostoses 7%
• Gene Expression Regulation 6%
• Fibroblast Growth Factor 2 6%
• Osteoblasts 5%
• Cell Adhesion 5%
• Sutures 5%
• Extracellular Matrix 5%
• Nucleotides 4%
• Real-Time Polymerase Chain Reaction 4%
• RNA 4%