Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B₁

Medicine & Life Sciences

• Aflatoxin B1 100%
• Human Activities 74%
• Vegetables 73%
• Cytochrome P-450 Enzyme System 72%
• methoxyresorufin-O-demethylase 67%
• Cytochrome P-450 CYP1A2 47%
• 5-Methoxypsoralen 42%
• Yeasts 40%
• Cytochrome P-450 Enzyme Inhibitors 39%
• Methoxsalen 35%
• Apigenin 34%
• Ficusin 34%
• Phytochemicals 26%
• Tryptophan 26%
• Pastinaca 24%
• Genetic Recombination 23%
• Petroselinum 21%
• Apium 20%
• naringenin 18%
• Daucus carota 18%
• Alleles 18%
• caffeic acid 17%
• Chlorogenic Acid 17%
• Gene Conversion 16%
• Biotransformation 14%
• Quercetin 14%
• Microsomes 13%
• Diploidy 13%
• Carcinogens 11%
• Saccharomyces cerevisiae 11%
• Cell Survival 9%
• Mutation 6%
• Enzymes 6%

Agriculture & Biology

• mutagenicity 84%
• aflatoxin B1 84%
• cytochrome P-450 69%
• vegetables 58%
• bergapten 37%
• methoxsalen 34%
• yeasts 32%
• apigenin 29%
• tryptophan 23%
• phytochemicals 21%
• parsnips 19%
• mitotic recombination 18%
• alleles 17%
• parsley 16%
• naringenin 15%
• celery 15%
• vegetable consumption 15%
• gene conversion 15%
• caffeic acid 13%
• chlorogenic acid 13%
• assays 13%
• carcinogens 13%
• microsomes 12%
• carrots 12%
• biotransformation 12%
• quercetin 12%
• diploidy 10%
• Saccharomyces cerevisiae 10%
• pretreatment 9%
• mutation 8%
• enzymes 5%
• cells 3%

Chemical Compounds

• Aflatoxin B1 94%
• Cytochrome 64%
• 5-Methoxypsoralen 42%
• Psoralen 34%
• Apigenin 32%
• Mitotic Recombination 24%
• Tryptophan 22%
• Chemopreventive 17%
• Naringenin 17%
• Aflatoxin 15%
• Chlorogenic Acid 15%
• Caffeic Acid 14%
• Quercetin 13%
• Cell Viability 12%
• Mutation 10%
• Strain 8%