APOBEC3F determinants of HIV-1 Vif sensitivity

Allison M. Land; Nadine M. Shaban; Leah Evans; Judd F. Hultquist; John S. Albin; Reuben S. Harris

doi:10.1128/JVI.02362-14

APOBEC3F determinants of HIV-1 Vif sensitivity

Allison M. Land, Nadine M. Shaban, Leah Evans, Judd F. Hultquist, John S. Albin, Reuben S. Harris

Molecular Biology (BMBB)

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12 Scopus citations

Abstract

HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

Original language	English (US)
Pages (from-to)	12923-12927
Number of pages	5
Journal	Journal of virology
Volume	88
Issue number	21
DOIs	https://doi.org/10.1128/JVI.02362-14
State	Published - 2014

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Publisher Copyright:
© 2014, American Society for Microbiology.

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title = "APOBEC3F determinants of HIV-1 Vif sensitivity",

abstract = "HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.",

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AU - Shaban, Nadine M.

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AU - Hultquist, Judd F.

AU - Albin, John S.

AU - Harris, Reuben S.

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AB - HIV-1 Vif counteracts restrictive APOBEC3 proteins by targeting them for proteasomal degradation. To determine the regions mediating sensitivity to Vif, we compared human APOBEC3F, which is HIV-1 Vif sensitive, with rhesus APOBEC3F, which is HIV-1 Vif resistant. Rhesus-human APOBEC3F chimeras and amino acid substitution mutants were tested for sensitivity to HIV-1 Vif. This approach identified the α3 and α4 helices of human APOBEC3F as important determinants of the interaction with HIV-1 Vif.

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APOBEC3F determinants of HIV-1 Vif sensitivity

Abstract

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