Apolipoprotein E genotype and incident ischemic stroke: The atherosclerosis risk in communities study

Jared D. Sturgeon, Aaron R. Folsom, Molly S. Bray, Eric Boerwinkle, Christie M. Ballantyne

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background and Purpose - A relationship between the apolipoprotein E (apoE) genotype and ischemic stroke has been inconsistently reported. We explored this relation in the Atherosclerosis Risk in Communities Study (ARIC). Methods - The ARIC cohort involves 15 792 men and women, aged 45 to 64 years at baseline and sampled from 4 U.S. communities. Between 1987 and 2001, 498 incident ischemic strokes occurred. Results - After stratifying by race and sex and adjusting for other nonlipid risk factors, there was no significant relation between the apoE genotype and incident stroke, except in black women (hazard ratio for e2 genotype relative to ε3/ε3=0.53; 95% CI, 0.28 to 0.99). Conclusions - For the most part, in this middle-aged sample, apoE was not a risk factor for incident ischemic stroke.

Original languageEnglish (US)
Pages (from-to)2484-2486
Number of pages3
JournalStroke
Volume36
Issue number11
DOIs
StatePublished - Nov 2005

Keywords

  • Apolipoprotein E
  • Ischemia
  • Stroke

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