TY - JOUR
T1 - Apolipoprotein E genotypes among diverse middle-aged and older Latinos
T2 - Study of Latinos-Investigation of Neurocognitive Aging results (HCHS/SOL)
AU - González, Hector M.
AU - Tarraf, Wassim
AU - Jian, Xueqiu
AU - Vásquez, Priscilla M.
AU - Kaplan, Robert
AU - Thyagarajan, Bharat
AU - Daviglus, Martha
AU - Lamar, Melissa
AU - Gallo, Linda C.
AU - Zeng, Donglin
AU - Fornage, Myriam
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.
AB - The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.
UR - http://www.scopus.com/inward/record.url?scp=85058516184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85058516184&partnerID=8YFLogxK
U2 - 10.1038/s41598-018-35573-3
DO - 10.1038/s41598-018-35573-3
M3 - Article
C2 - 30546063
AN - SCOPUS:85058516184
SN - 2045-2322
VL - 8
JO - Scientific reports
JF - Scientific reports
IS - 1
M1 - 17578
ER -