Apolipoprotein E4 and tau allele frequencies among Choctaw Indians

J. Neil Henderson, Richard Crook, Julia Crook, John Hardy, Luisa Onstead, Linda Carson-Henderson, Pat Mayer, Bea Parker, Birdie Williams, Ronald Petersen

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Apolipoprotein genotyping and tau haplotyping were carried out on a series of cases with dementia and controls from the Choctaw Nation of Oklahoma. Both the Apolipoprotein E4 allele frequency and the tau H2 haplotype frequency were low in the Choctaw compared with Caucasians and there was the possibility that the association between dementia and the E4 allele was weaker than in Caucasians.

Original languageEnglish (US)
Pages (from-to)77-79
Number of pages3
JournalNeuroscience Letters
Volume324
Issue number1
DOIs
StatePublished - May 10 2002

Bibliographical note

Funding Information:
The support of the Choctaw Tribal Board for this study is appreciated: supported by the NIA/NIH Mayo Clinic Alzheimer Center.

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Choctaw
  • Genetics
  • Tau

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