Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell

Justin J. Taylor, Kathryn A Pape, Holly R. Steach, Marc Jenkins

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

When exposed to antigens, naïve B cells differentiate into different types of effector cells: antibody-producing plasma cells, germinal center cells, or memory cells. Whether an individual naïve B cell can produce all of these different cell fates remains unclear. Using a limiting dilution approach, we found that many individual naïve B cells produced only one type of effector cell subset, whereas others produced all subsets. The capacity to differentiate into multiple subsets was a characteristic of clonal populations that divided many times and resisted apoptosis, but was independent of isotype switching. Antigen receptor affinity also influenced effector cell differentiation. These findings suggest that diverse effector cell types arise in the primary immune response as a result of heterogeneity in responses by individual naïve B cells.

Original languageEnglish (US)
Pages (from-to)784-787
Number of pages4
JournalScience
Volume347
Issue number6223
DOIs
StatePublished - Feb 13 2015

Bibliographical note

Publisher Copyright:
© 2015, american association for the advancement of science. All rights reserved.

Fingerprint Dive into the research topics of 'Apoptosis and antigen affinity limit effector cell differentiation of a single naïve B cell'. Together they form a unique fingerprint.

Cite this