Applications of Powder X-Ray Diffraction in Small Molecule Pharmaceuticals: Achievements and Aspirations

Naveen K. Thakral, Roger L. Zanon, Ron C. Kelly, Seema Thakral

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Since the discovery of X-ray diffraction and its potential to elucidate crystal symmetry, powder X-ray diffraction has found diverse applications in the field of pharmaceutical sciences. This review summarizes significant achievements of the technique during various stages of dosage form development. Improved understanding of the principle involved and development of automated hardware and reliable software have led to increased instrumental sensitivity and improved data analysis. These advances continue to expand the applications of powder X-ray diffraction to emerging research fields such as amorphous systems, mechanistic understanding of phase transformations, and “Quality by Design” in formulation development.

Original languageEnglish (US)
Pages (from-to)2969-2982
Number of pages14
JournalJournal of Pharmaceutical Sciences
Volume107
Issue number12
DOIs
StatePublished - Dec 2018

Bibliographical note

Funding Information:
Dr Dubravka Sisak Jung is acknowledged for her insightful discussions and comments about the HPC detector technology.

Keywords

  • formulations
  • phase transformations
  • physical characterization
  • polymorphism
  • powder X-ray diffraction

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