Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid

Kamil Růžička, Lucia C. Strader, Aurélien Bailly, Haibing Yang, Joshua Blakeslee, Łukasz Łangowski, Eliška Nejedlá, Hironori Fujita, Hironori Itoh, Kunihiko Syono, Jan Hejátko, William M Gray, Enrico Martinoia, Markus Geisler, Bonnie Bartel, Angus S. Murphy, Jiří Friml

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

Differential distribution of the plant hormone auxin within tissues mediates a variety of developmental processes. Cellular auxin levels are determined by metabolic processes including synthesis, degradation, and (de)conjugation, as well as by auxin transport across the plasma membrane. Whereas transport of free auxins such as naturally occurring indole-3-acetic acid (IAA) is well characterized, little is known about the transport of auxin precursors and metabolites. Here, we identify amutation in the ABCG37 gene of Arabidopsis that causes the polar auxin transport inhibitor sensitive1 (pis1) phenotype manifested by hypersensitivity to auxinic compounds. ABCG37 encodes the pleiotropic drug resistance transporter that transports a range of synthetic auxinic compounds as well as the endogenous auxin precursor indole-3-butyric acid (IBA), but not free IAA. ABCG37 and its homolog ABCG36 act redundantly at outermost root plasma membranes and,unlike established IAA transporters from the PIN and ABCB families, transport IBA out of the cells. Our findings explore possible novel modes of regulating auxin homeostasis and plant development by means of directional transport of the auxin precursor IBA and presumably also other auxin metabolites.

Original languageEnglish (US)
Pages (from-to)10749-10753
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume107
Issue number23
DOIs
StatePublished - Jun 8 2010

Keywords

  • Auxin synthesis
  • IBA transport
  • PDR8
  • PDR9

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