Arthritis gene therapy's first death

Christopher H. Evans, Steven C. Ghivizzani, Paul D. Robbins

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

In July 2007 a subject died while enrolled in an arthritis gene therapy trial. The study was placed on clinical hold while the circumstances surrounding this tragedy were investigated. Early in December 2007 the Food and Drug Administration removed the clinical hold, allowing the study to resume with minor changes to the protocol. In the present article we collate the information we were able to obtain about this clinical trial and discuss it in the wider context of arthritis gene therapy.

Original languageEnglish (US)
Article number110
JournalArthritis Research and Therapy
Volume10
Issue number3
DOIs
StatePublished - Feb 27 2008
Externally publishedYes

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