Aspirin in childhood acute ischemic stroke: The evidence for treatment and efficacy testing

Alexander A. Boucher, J. Michael Taylor, Lori Luchtman-Jones

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Aspirin is the most commonly prescribed antiplatelet agent worldwide, but evidence supporting its use varies by age and disease process. Despite its frequent use in childhood acute ischemic stroke prevention and management, major knowledge gaps exist about optimal pediatric aspirin use, particularly in this setting, where high-quality clinical trials are urgently needed. This review focuses upon the evidence for aspirin use in childhood acute ischemic stroke, includes a summary of aspirin pharmacology to highlight misconceptions and common clinical situations which may limit its efficacy, and discusses the techniques and potential role of laboratory monitoring of aspirin efficacy in children.

Original languageEnglish (US)
Article numbere27665
JournalPediatric Blood and Cancer
Volume66
Issue number6
DOIs
StatePublished - Jun 2019
Externally publishedYes

Keywords

  • hemostasis and thrombosis
  • non-malignant hematology
  • pharmacology

PubMed: MeSH publication types

  • Journal Article
  • Review

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