Assessing by modeling the consequences of increased recombination in recurrent selection of oryza sativa and brassica rapa

Elise Tourrette, Rex Bernardo, Matthieu Falque, Olivier C. Martin

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Meiotic recombination generates genetic diversity but in most species the number of crossovers per meiosis is limited. Previous modeling studies showed that increasing recombination can enhance response to selection. However, such studies did not assume a specific method of modifying recombination. Our objective was to test whether two methods used to increase recombination in plants could increase genetic gain in a population undergoing recurrent selection such as in genomic selection programs. The first method, in Oryza sativa, used a mutant of anti-crossover genes, increasing global recombination without affecting the recombination landscape shape. The second one used the ploidy level of a cross between Brassica rapa and Brassica napus, increasing recombination especially in pericentromeric regions. Our modeling framework used these recombination landscapes and sampled quantitative trait loci positions from the actual gene distributions. We simulated selection programs with initially a cross between two inbred lines, for two species. Increased recombination enhanced the response to selection. The amount of enhancement in the cumulative gain largely depended on the species and the number of quantitative trait loci (2, 10, 20, 50, 200 or 1000 per chromosome). Genetic gains were increased up to 30% after 20 generations. Furthermore, increasing recombination in cold regions was the most effective: the gain was larger by 25% with the first method and 34% with the second one in B. rapa, and 12% compared to 16% in O. sativa. In summary, increased recombination enhances the genetic gain in long-term selection programs, with visible effects after four to five generations.

Original languageEnglish (US)
Pages (from-to)4169-4181
Number of pages13
JournalG3: Genes, Genomes, Genetics
Volume9
Issue number12
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
We thank S. Mezmouk, E. Jenczewski, J.C. Motamayor, D. Livingston, C.E. Durel and R. Mercier for constructive comments and discussion. This work has benefited from a French State grant (LabEx Saclay Plant Sciences-SPS, ANR-10-LABX-0040-SPS), managed by the French National Research Agency under an “Investments for the Future” program (ANR-11-IDEX-0003-02) and KWS, MARS, and Secobra which co-funded the salary of ET and Ecole Doctorale FIRE - Program Bettencourt for support.

Publisher Copyright:
Copyright © 2019 Tourrette et al.

Keywords

  • Genetics
  • Genomic
  • Plant breeding
  • Quantitative
  • Selection
  • Simulation

Fingerprint Dive into the research topics of 'Assessing by modeling the consequences of increased recombination in recurrent selection of oryza sativa and brassica rapa'. Together they form a unique fingerprint.

Cite this