The significance of the oral microbiome in the generation of the nitric oxide (NO) via the enterosalivary nitrate-nitrite-nitric oxide pathway is increasingly recognized, directly linking the oral microbiome to cardiometabolic outcomes influenced by NO. The objective of this chapter is to outline a strategy of identifying pathway-specific bacterial taxa or predicted genes of interest from 16S rRNA data, specifically in the enterosalivary pathway of nitrate reduction, and analyzing their relationship with cardiometabolic outcomes using multivariable regression models.
|Original language||English (US)|
|Title of host publication||Methods in Molecular Biology|
|Publisher||Humana Press Inc.|
|Number of pages||22|
|State||Published - 2021|
|Name||Methods in Molecular Biology|
Bibliographical notePublisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.
- Nitrate, Nitrite, Nitric oxide pathway
- Oral microbiome
- Pathway activity prediction