Abstract
Aim: Hyperuricemia commonly causes gout. Minnesota Hmong exhibit a two-to five-fold higher prevalence of gout versus non-Hmong. To elucidate a possible genomic contribution to this disparity, prevalence of risk alleles for hyperuricemia in Hmong was compared with European (CEU) and Han-Chinese (CHB). Methods: In total, 235 Hmong were genotyped for eight SNPs representing five candidate genes (SLC22A12, SLC2A9, ABCG2, SLC17A1 and PDZK1). Results: The frequency of seven out of eight risk alleles in the Hmong was significantly different than CEU; six higher and one with lower prevalence. The frequency of three out of eight risk alleles in the Hmong was significantly different than CHB; two higher and one with lower prevalence. Conclusion: Hyperuricemia risk alleles are more prevalent in the Hmong than CEU and CHB.
Original language | English (US) |
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Pages (from-to) | 429-440 |
Number of pages | 12 |
Journal | Personalized Medicine |
Volume | 13 |
Issue number | 5 |
DOIs | |
State | Published - Sep 2016 |
Bibliographical note
Publisher Copyright:© 2016 Future Medicine Ltd.
Keywords
- Hmong
- SNPs
- hyperuricemia