TY - GEN
T1 - Assessment of resting-state cerebral blood flow in fibromyalgia patients using arterial spin labelling.
T2 - 43rd Annual Meeting of the Society for Neuroscience
AU - Moana-Filho, E. J.
AU - Tchivileva, I. E.
AU - Gracely, R.
PY - 2013
Y1 - 2013
N2 - Widespread musculoskeletal pain is the hallmark symptom reported by fibromyalgia patients. Such pain presents in a continuous and rarely remitting fashion, and current understanding of its pathophysiology is limited. By means of resting functional magnetic resonance imaging (fMRI) using blood oxygen-level dependent signal, recent studies showed imbalanced brain functional connectivity in fibromyalgia patients when compared to healthy controls as well as an association between resting brain activity in patients and spontaneous clinical pain level. Arterial spin labelling (ASL) is an fMRI technique that allows quantitative measurement of whole-brain cerebral blood flow (CBF) in a non-invasive fashion, with the additional advantage of providing comparable measures over time. These characteristics, plus reduced susceptibility-related signal loss, make ASL an apt tool to assess CBF in patients suffering ongoing, tonic widespread pain. Thirty fibromyalgia female patients, who reported clinical pain characteristics and completed questionnaires for mood disorders, underwent two runs of pseudo continuous ASL imaging collected at rest. Both runs were averaged and processed to obtain perfusion images showing CBF in absolute units (ml of blood/100 g of tissue/min). Region of interest (ROI) analysis calculated mean CBF in a priori selected anatomical brain areas typically related to pain perception (Thalamus, SI, SII, insula and anterior cingulate cortex (ACC)). Spearman’s rank correlation coefficient was used to measure correlations between CBF and clinical characteristics. All ROI mean CBF measurements showed positive correlations between each other (.369
AB - Widespread musculoskeletal pain is the hallmark symptom reported by fibromyalgia patients. Such pain presents in a continuous and rarely remitting fashion, and current understanding of its pathophysiology is limited. By means of resting functional magnetic resonance imaging (fMRI) using blood oxygen-level dependent signal, recent studies showed imbalanced brain functional connectivity in fibromyalgia patients when compared to healthy controls as well as an association between resting brain activity in patients and spontaneous clinical pain level. Arterial spin labelling (ASL) is an fMRI technique that allows quantitative measurement of whole-brain cerebral blood flow (CBF) in a non-invasive fashion, with the additional advantage of providing comparable measures over time. These characteristics, plus reduced susceptibility-related signal loss, make ASL an apt tool to assess CBF in patients suffering ongoing, tonic widespread pain. Thirty fibromyalgia female patients, who reported clinical pain characteristics and completed questionnaires for mood disorders, underwent two runs of pseudo continuous ASL imaging collected at rest. Both runs were averaged and processed to obtain perfusion images showing CBF in absolute units (ml of blood/100 g of tissue/min). Region of interest (ROI) analysis calculated mean CBF in a priori selected anatomical brain areas typically related to pain perception (Thalamus, SI, SII, insula and anterior cingulate cortex (ACC)). Spearman’s rank correlation coefficient was used to measure correlations between CBF and clinical characteristics. All ROI mean CBF measurements showed positive correlations between each other (.369
M3 - Other contribution
CY - San Diego, CA
ER -