TY - JOUR
T1 - Association between Immunoglobulin E Levels and Kaposi Sarcoma in African Adults with Human Immunodeficiency Virus Infection
AU - Byakwaga, Helen
AU - Barbachano-Guerrero, Arturo
AU - Wang, Dongliang
AU - Mcallister, Shane
AU - Naphri, Kamal
AU - Laker-Oketta, Miriam
AU - Muzoora, Conrad
AU - Hunt, Peter W.
AU - Martin, Jeffrey
AU - King, Christine A.
N1 - Publisher Copyright:
© 2020 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - It has been demonstrated that activated mast cells (MCs) are enriched in Kaposi sarcoma (KS) tumors and contribute to the inflammatory microenvironment. Mechanisms driving MC activation, however, are incompletely understood. We sought to understand whether immunoglobulin E (IgE), a potent activator of MCs, was associated with KS incidence and severity. In a cross-sectional study of untreated human immunodeficiency virus (HIV)-infected adults with or without KS in Uganda, we found that patients with KS had higher plasma IgE levels than those without KS. After adjustment for age, sex, CD4+ T-cell count, and HIV RNA levels, there was a dose-response relationship between plasma IgE levels and the presence and severity of KS. Higher eosinophil counts were also associated with IgE levels, and plasma interleukin 33 concentrations were higher in individuals with KS. These findings suggest that IgE-driven atopic inflammation may contribute the pathogenesis of KS. Therapies targeting IgE-mediated MC activation thus might represent a novel approach for treatment or prevention of KS.
AB - It has been demonstrated that activated mast cells (MCs) are enriched in Kaposi sarcoma (KS) tumors and contribute to the inflammatory microenvironment. Mechanisms driving MC activation, however, are incompletely understood. We sought to understand whether immunoglobulin E (IgE), a potent activator of MCs, was associated with KS incidence and severity. In a cross-sectional study of untreated human immunodeficiency virus (HIV)-infected adults with or without KS in Uganda, we found that patients with KS had higher plasma IgE levels than those without KS. After adjustment for age, sex, CD4+ T-cell count, and HIV RNA levels, there was a dose-response relationship between plasma IgE levels and the presence and severity of KS. Higher eosinophil counts were also associated with IgE levels, and plasma interleukin 33 concentrations were higher in individuals with KS. These findings suggest that IgE-driven atopic inflammation may contribute the pathogenesis of KS. Therapies targeting IgE-mediated MC activation thus might represent a novel approach for treatment or prevention of KS.
KW - Africa
KW - HIV
KW - IL-33
KW - Immunoglobulin E (IgE)
KW - KSHV
KW - Kaposi sarcoma
KW - mast cell
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U2 - 10.1093/infdis/jiaa340
DO - 10.1093/infdis/jiaa340
M3 - Article
C2 - 32561934
AN - SCOPUS:85099429204
SN - 0022-1899
VL - 223
SP - 101
EP - 108
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -