Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer

Kristin E. Anderson, Trista W. Johnson, DeAnn Lazovich, Aaron R. Folsom

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

Laboratory studies indicate that non-steroidal anti-inflammatory drugs (NSAIDs) may inhibit pancreatic cancer, but epidemiologic data to support this finding are limited. We conducted a prospective study from 1992 through 1999 among 28 283 post-menopausal women who lived in Iowa to examine the association between the self-reported use of aspirin and other NSAIDs and the incidence of pancreatic cancer. Eighty incident cases of pancreatic cancer were identified during 7 years of follow-up. The multivariate-adjusted relative risk of pancreatic cancer associated with any current use of aspirin versus no use was 0.57 (95% confidence interval = 0.36 to 0.90). There was a trend of decreasing risk of pancreatic cancer incidence with increasing frequency of aspirin use per week (Ptrend = .005). Nonaspirin NSAID use was not associated with incident pancreatic cancer. These data indicate that aspirin might be chemopreventive for pancreatic cancer.

Original languageEnglish (US)
Pages (from-to)1168-1171
Number of pages4
JournalJournal of the National Cancer Institute
Volume94
Issue number15
DOIs
StatePublished - Aug 7 2002

Fingerprint

Dive into the research topics of 'Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer'. Together they form a unique fingerprint.

Cite this