Association between sleep disordered breathing and electrocardiographic markers of atrial abnormalities: The MESA study

Younghoon Kwon, Jeffrey R. Misialek, Daniel Duprez, Alvaro Alonso, David R. Jacobs, Susan R. Heckbert, Susan Redline, Elsayed Z. Soliman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Sleep disordered breathing (SDB) is a common condition increasingly recognized as a risk factor for atrial fibrillation (AF).1,2 Long P wave duration, an electrocardiographic (ECG) marker of atrial remodelling, was shown in patients with SDB highlighting the potential role of atrial remodelling in linking SDB to AF.3 This study was limited by small sample sizes of selected patients from sleep clinics. Emerging literature indicates that an ECG marker for P wave terminal force (PTF) identifies atrial abnormalities strongly linked to AF and stroke.4 However, the association between PTF and SDB has not been explored previously. Therefore, we sought to examine the association of ECG markers of left atrial (LA) abnormalities in relation to SDB in a large, representative population in this study, with a specific interest in PTF in V1(PTFV1) as a sensitive marker of LA abnormalities.

Original languageEnglish (US)
Pages (from-to)1759-1766
Number of pages8
JournalEuropace
Volume19
Issue number11
DOIs
StatePublished - Nov 1 2017

Bibliographical note

Funding Information:
This research was supported by contracts N01 HC 95159, N01 HC 95160, N01 HC 95161, N01 HC 95162, N01 HC 95163, N01 HC 95164, N01 HC 95165, N01 HC 95166, N01 HC 95167, N01 HC 95168 and N01 HC 95169 from the NHBLI, by grants UL1 TR 000040, UL1 RR 025005 from NCRR, R01HL098433 (MESA Sleep) and T32 HL069764.

Publisher Copyright:
© The Author 2016. For permissions.

Keywords

  • Atrial fibrillation
  • Epidemiology
  • P wave index
  • P wave terminal force
  • Sleep apnoe
  • Sleep disordered breathing

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