TY - JOUR
T1 - Association between type 1 diabetes mellitus and deposits in the semicircular canals
AU - Yoda, Shigetoshi
AU - Cureoglu, Sebahattin
AU - Yildirim-Baylan, Muzeyyen
AU - Morita, Norimasa
AU - Fukushima, Hisaki
AU - Harada, Tamotsu
AU - Paparella, Michael
PY - 2011/9
Y1 - 2011/9
N2 - Objective. To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellitus patients and normal controls. Study Design. Case-control histopathologic human temporal bone study. Setting. Otopathology laboratory in a tertiary academic medical center. Subjects and Methods. Twenty-eight temporal bones from 14 patients with type 1 diabetes mellitus and 56 normal temporal bones from 28 age-matched individuals were histopathologically examined. The cupula and lumina of the semicircular canals were examined for evidence of deposits. Results. The prevalence of cupular and free-floating deposits in the lateral and posterior semicircular canals was significantly higher in type 1 diabetes mellitus patients compared with normal temporal bones (lateral, cupular deposits, odds ratio [OR], 5.47; 95% confidence interval [CI], 1.43 to 21.02; free-floating deposits, OR, 8.25; 95% CI, 2.42 to 27.85; posterior, cupular deposits, OR, 41.73; 95% CI, 5.96 to 275.50; free-floating deposits, OR, 7.44; 95% CI, 1.91 to 28.53). The prevalence of these deposits was associated with the duration of disease rather than with aging. Conclusion. The findings suggest that type 1 diabetes mellitus is associated with cupular and free-floating deposits in the semi-circular canals. The patients with type 1 diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.
AB - Objective. To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellitus patients and normal controls. Study Design. Case-control histopathologic human temporal bone study. Setting. Otopathology laboratory in a tertiary academic medical center. Subjects and Methods. Twenty-eight temporal bones from 14 patients with type 1 diabetes mellitus and 56 normal temporal bones from 28 age-matched individuals were histopathologically examined. The cupula and lumina of the semicircular canals were examined for evidence of deposits. Results. The prevalence of cupular and free-floating deposits in the lateral and posterior semicircular canals was significantly higher in type 1 diabetes mellitus patients compared with normal temporal bones (lateral, cupular deposits, odds ratio [OR], 5.47; 95% confidence interval [CI], 1.43 to 21.02; free-floating deposits, OR, 8.25; 95% CI, 2.42 to 27.85; posterior, cupular deposits, OR, 41.73; 95% CI, 5.96 to 275.50; free-floating deposits, OR, 7.44; 95% CI, 1.91 to 28.53). The prevalence of these deposits was associated with the duration of disease rather than with aging. Conclusion. The findings suggest that type 1 diabetes mellitus is associated with cupular and free-floating deposits in the semi-circular canals. The patients with type 1 diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.
KW - Deposit
KW - Human temporal bone
KW - Positional vertigo
KW - Type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=80055081585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80055081585&partnerID=8YFLogxK
U2 - 10.1177/0194599811407610
DO - 10.1177/0194599811407610
M3 - Article
C2 - 21572081
AN - SCOPUS:80055081585
SN - 0194-5998
VL - 145
SP - 458
EP - 462
JO - Otolaryngology - Head and Neck Surgery
JF - Otolaryngology - Head and Neck Surgery
IS - 3
ER -