Association between type 1 diabetes mellitus and deposits in the semicircular canals

Shigetoshi Yoda, Sebahattin Cureoglu, Muzeyyen Yildirim-Baylan, Norimasa Morita, Hisaki Fukushima, Tamotsu Harada, Michael M. Paparella

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Objective. To compare the prevalence of cupular and free-floating deposits in the semicircular canals between temporal bones of type 1 diabetes mellitus patients and normal controls. Study Design. Case-control histopathologic human temporal bone study. Setting. Otopathology laboratory in a tertiary academic medical center. Subjects and Methods. Twenty-eight temporal bones from 14 patients with type 1 diabetes mellitus and 56 normal temporal bones from 28 age-matched individuals were histopathologically examined. The cupula and lumina of the semicircular canals were examined for evidence of deposits. Results. The prevalence of cupular and free-floating deposits in the lateral and posterior semicircular canals was significantly higher in type 1 diabetes mellitus patients compared with normal temporal bones (lateral, cupular deposits, odds ratio [OR], 5.47; 95% confidence interval [CI], 1.43 to 21.02; free-floating deposits, OR, 8.25; 95% CI, 2.42 to 27.85; posterior, cupular deposits, OR, 41.73; 95% CI, 5.96 to 275.50; free-floating deposits, OR, 7.44; 95% CI, 1.91 to 28.53). The prevalence of these deposits was associated with the duration of disease rather than with aging. Conclusion. The findings suggest that type 1 diabetes mellitus is associated with cupular and free-floating deposits in the semi-circular canals. The patients with type 1 diabetes mellitus with a longer duration of disease have an increased probability of suffering from benign paroxysmal positional vertigo.

Original languageEnglish (US)
Pages (from-to)458-462
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Volume145
Issue number3
DOIs
StatePublished - Sep 2011

Keywords

  • Deposit
  • Human temporal bone
  • Positional vertigo
  • Type 1 diabetes mellitus

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