Association of antihypertensive agents and blood lipids in a population-based survey

Daniel Strickland; J. Michael Sprafka; Russell V Luepker; Richard H. Grimm

doi:10.1097/00001648-199401000-00014

Association of antihypertensive agents and blood lipids in a population-based survey

Daniel Strickland, J. Michael Sprafka, Russell V Luepker, Richard H. Grimm

Epidemiology

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12 Scopus citations

Abstract

Clinical trials indicate that many antihypertensive medications alter blood lipids. These lipid changes may be of sufficient magnitude to influence subsequent coronary heart disease rates. We examined this association in a large population sample (N = 15,918, ages 25–74, 12% on antihypertensive medication) surveyed cross-sectionally from 1980 to 1986. Subjects taking antihypertensive medication had a mean serum total cholesterol 4.0 mg per dl higher than those not taking these medications after we adjusted for age, sex, weight, smoking, alcohol, blood pressure, and exercise. High- density lipoprotein cholesterol was lower in the medicated group by 2.5 mg per dl. There was no evidence that the length of medication use was related to lipid levels.

Original language	English (US)
Pages (from-to)	96-101
Number of pages	6
Journal	Epidemiology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1097/00001648-199401000-00014
State	Published - Jan 1994

Keywords

Antihypertensives
Cholesterol levels
Coronary disease
Hypertension
Lipoproteins
Population surveys

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Clinical trials indicate that many antihypertensive medications alter blood lipids. These lipid changes may be of sufficient magnitude to influence subsequent coronary heart disease rates. We examined this association in a large population sample (N = 15,918, ages 25–74, 12% on antihypertensive medication) surveyed cross-sectionally from 1980 to 1986. Subjects taking antihypertensive medication had a mean serum total cholesterol 4.0 mg per dl higher than those not taking these medications after we adjusted for age, sex, weight, smoking, alcohol, blood pressure, and exercise. High- density lipoprotein cholesterol was lower in the medicated group by 2.5 mg per dl. There was no evidence that the length of medication use was related to lipid levels.",

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AU - Sprafka, J. Michael

AU - Luepker, Russell V

AU - Grimm, Richard H.

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AB - Clinical trials indicate that many antihypertensive medications alter blood lipids. These lipid changes may be of sufficient magnitude to influence subsequent coronary heart disease rates. We examined this association in a large population sample (N = 15,918, ages 25–74, 12% on antihypertensive medication) surveyed cross-sectionally from 1980 to 1986. Subjects taking antihypertensive medication had a mean serum total cholesterol 4.0 mg per dl higher than those not taking these medications after we adjusted for age, sex, weight, smoking, alcohol, blood pressure, and exercise. High- density lipoprotein cholesterol was lower in the medicated group by 2.5 mg per dl. There was no evidence that the length of medication use was related to lipid levels.

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KW - Cholesterol levels

KW - Coronary disease

KW - Hypertension

KW - Lipoproteins

KW - Population surveys

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Association of antihypertensive agents and blood lipids in a population-based survey

Abstract

Keywords

UN SDGs

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