Association of CYP1A1 polymorphisms with breast cancer in North Indian women

Neetu Singh, Amit Kumar Mitra, Vivek Kumar Garg, Amit Agarwal, Mandira Sharma, Rashmi Chaturvedi, Srikanta Kumar Rath

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Cytochrome P-450 (CYP) 1A1 is a candidate gene for low penetrance breast cancer (BC) susceptibility. Evidences demonstrate that ethnic differences in BC incidence may be partly due to genetic factors, including polymorphisms in the genes. In the present case control study four CYP1A1 gene polymorphisms, m1 (T6235C), m2 (A4889G), m3 (T5639C), and m4 (C4887A) were studied for their association with BC conjointly with the known risk factors such as age, menopausal status, diet, and life style. Polymorphisms of CYP1A1 gene were detected by PCR-RFLP method. The homozygous mutant (G/G) of m2 polymorphism was significantly associated with BC. Consequently, association of both m2 heterozygous mutant genotype (A/G) and combined group [homozygous (G/G) plus heterozygous (A/G) mutant genotype] showed association with postmenopausal women. Incidences of BC were also found to be independent of clinicopathological factors except heterozygous mutant genotype (A/G) m2 showed association with dietary factors and high grade tumors while homozygous mutant (G/G) m2 showed association with ER/PR-positive BC cases. Wildtype m3 was observed in all the subjects in cases as well as in controls. No significant association was observed between m1 and m3 polymorphisms and BC risk in all the subjects as well as when stratified into pre- and postmenopausal subjects. This indicates that out of m1 and m2 polymorphisms that have been reported in Asians, only m2 is associated with North Indians.

Original languageEnglish (US)
Pages (from-to)587-597
Number of pages11
JournalOncology Research
Volume16
Issue number12
DOIs
StatePublished - Dec 1 2007

Keywords

  • Breast cancer
  • CYP1A1 polymorphism

Fingerprint Dive into the research topics of 'Association of CYP1A1 polymorphisms with breast cancer in North Indian women'. Together they form a unique fingerprint.

Cite this