A rapid L-proline catalyzed direct aldol reaction between various aldehydes and acetone was achieved using PEG as the solvent with comparable enantioselectivities and yields to those obtained in other solvents. Recycling the catalyst and solvent (PEG) was possible 10 times without loss of activity.
Bibliographical noteFunding Information:
We C.N., N.R.K. and S.S.S. thank CSIR New Delhi for financial support.
- Asymmetric aldol reaction