Abstract
α-Alkylated azocane-2-carboxylic acid methyl esters 5 were synthesized with excellent enantiomeric excess (>96%) in four steps starting from optically active β-keto esters 1. The synthesis involved tetrazole formation, reduction, protection, and oxidation.
Original language | English (US) |
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Pages (from-to) | 17-20 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 33 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 1992 |
Keywords
- Schmidt
- asymmetric synthesis
- tetrazoles
- α-alkylated azocane-2-carboxylic acids
- α-alkylated α-amino acids