Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids

Gunda I. Georg; Xiangming Guan; Joydeep Kant

doi:10.1016/S0960-894X(00)80245-0

Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids

Gunda I. Georg, Xiangming Guan, Joydeep Kant

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The synthesis of optically active α-alkylated azepane-2-carboxylic acid esters 3 was achieved via Schmidt rearrangement of optically active ethyl 2-oxo-1-alkyl-cyclohexanecarboxylates 1 followed by selective reduction of the amide carbonyl group.

Original language	English (US)
Pages (from-to)	125-128
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	1
Issue number	2
DOIs	https://doi.org/10.1016/S0960-894X(00)80245-0
State	Published - 1991

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@article{16b59f2962314918a5dbbc99fcb4d564,

title = "Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids",

abstract = "The synthesis of optically active α-alkylated azepane-2-carboxylic acid esters 3 was achieved via Schmidt rearrangement of optically active ethyl 2-oxo-1-alkyl-cyclohexanecarboxylates 1 followed by selective reduction of the amide carbonyl group.",

author = "Georg, {Gunda I.} and Xiangming Guan and Joydeep Kant",

year = "1991",

doi = "10.1016/S0960-894X(00)80245-0",

language = "English (US)",

volume = "1",

pages = "125--128",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Asymmetric synthesis of α-alkylated α-amino acids

T2 - azepane-2-carboxylic acids

AU - Georg, Gunda I.

AU - Guan, Xiangming

AU - Kant, Joydeep

PY - 1991

Y1 - 1991

N2 - The synthesis of optically active α-alkylated azepane-2-carboxylic acid esters 3 was achieved via Schmidt rearrangement of optically active ethyl 2-oxo-1-alkyl-cyclohexanecarboxylates 1 followed by selective reduction of the amide carbonyl group.

AB - The synthesis of optically active α-alkylated azepane-2-carboxylic acid esters 3 was achieved via Schmidt rearrangement of optically active ethyl 2-oxo-1-alkyl-cyclohexanecarboxylates 1 followed by selective reduction of the amide carbonyl group.

UR - http://www.scopus.com/inward/record.url?scp=0025804646&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025804646&partnerID=8YFLogxK

U2 - 10.1016/S0960-894X(00)80245-0

DO - 10.1016/S0960-894X(00)80245-0

M3 - Article

AN - SCOPUS:0025804646

SN - 0960-894X

VL - 1

SP - 125

EP - 128

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

Asymmetric synthesis of α-alkylated α-amino acids: azepane-2-carboxylic acids

Abstract

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