Asymmetric synthesis of α-alkylated α-amino acids: azocane-2-carboxylic acids

Gunda U. Georg, Xiangming Guan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

α-Alkylated azocane-2-carboxylic acid methyl esters 5 were synthesized with excellent enantiomeric excess (>96%) in four steps starting from optically active β-keto esters 1. The synthesis involved tetrazole formation, reduction, protection, and oxidation.

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number1
DOIs
StatePublished - Jan 1 1992

Keywords

  • Schmidt
  • asymmetric synthesis
  • tetrazoles
  • α-alkylated azocane-2-carboxylic acids
  • α-alkylated α-amino acids

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