Asymmetric synthesis of a protected dihydroxypiperazic acid derivative

S. Chandrasekhar, Ganney Parimala, Bhoopendra Tiwari, Ch Narsihmulu, G. Dattatreya Sarma

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A short and flexible route for the synthesis of 1,2-diisopropyl-3-methyl- (3S,4R,5R)-4,5-dihydroxyhexahydro-1,2,3-pyridazinetricarboxylate, from readily available acrolein, is described. This approach involves an asymmetric α-hydrazination, dihydroxylation and intramolecular cyclisation as key steps.

Original languageEnglish (US)
Pages (from-to)1677-1682
Number of pages6
JournalSynthesis
Issue number11
DOIs
StatePublished - Jun 19 2007
Externally publishedYes

Keywords

  • Dihydroxylation
  • Intramolecular cyclisation
  • L-proline
  • Piperazic acid
  • α-hydrazination

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