An efficient asymmetric synthesis of (+)-tetrahydropseudodistomin is described. The important synthetic features include a Maruoka asymmetric allylation and a Sharpless asymmetric dihydroxylation as key steps for the generation of chirality at C-2, -4, and -5 of the trisubstituted piperidine ring.
Bibliographical noteFunding Information:
S.S.S. thanks the CSIR, New Delhi and N.K. thanks the UGC, New Delhi, for financial support and S.C. thanks the DST, New Delhi, for a grant.
- Marouka asymmetric allylation
- Sharpless asymmetric dihydroxylation