Abstract
PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3896-3903 |
| Number of pages | 8 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 47 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2006 |
Access
Fingerprint Dive into the research topics of 'Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study'. Together they form a unique fingerprint.
Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study. / Levine, Richard A.; Demirel, Shaban; Fan, Juanjuan; Keltner, John L.; Johnson, Chris A.; Kass, Michael A.; Budenz, Donald L.; Fantes, Francisco E.; Gedde, Steven J.; Parrish, Richard K.; Del Calvo, Madeline L.; Harbin, Thomas S.; McManus, Paul; Patorgis, Charles J.; Hooper, Montana L.; Goldstein, Stacey S.; Lee, Debbie L.; Morton, Lea; Perry, Marianne L.; Long, Teresa A.; Smith, Shelly R.; Wright, Julie M.; Gross, Ronald L.; Orengo-Nania, Silvia; Frady, Pamela M.; Slight, Benita D.; Cioffi, George A.; Jamil, Annisa L.; Mansberger, Steven; Patterson, Emily L.; Sherman, Kathryn; Fraser, Jo Anne M.; Beck, Allen D.; Costarides, Anastasias; Hylton, Camilele M.; Leef, Donna; Imami, Nauman R.; Darnley-Fisch, Deborah; Fantin, Aldo; Gutkowski, Melanie; Carnegie, Elizabeth; Rock, Sheila; Zack, Donald J.; Abrams, Donald A.; Congdon, Nathan G.; Copeland, Robert A.; Friedman, David S.; Hemady, Ramzi; Higginbotham, Eve J.; Jampel, Henry D.; Pollack, Irvin P.; Quigley, Harry A.; Robin, Alan L.; Scott, Rachel; Keel, Felicia; Levin, Lisa; Powdrill, Kevin L.; Priest-Reed, Robyn; Coleman, Anne L.; Baker, Richard S.; Dang, Y. P.; Giaconi, Jo Ann A.; Law, Simon K.; Ballenberg, Bobbie; Murillo, Salvador; Sharma, Manju; Bergstrom, Terry J.; Bruno, Christina A.; Moroi, Sayoko E.; Pollack-Rundle, Carol J.; Tehranisa, Michelle A.; Hughes, Bret A.; Allen, Monica Y.; Juzych, Mark S.; McDermott, Mark L.; Ramocki, John M.; Allen, Juan; Schulz, Laura L.; O'Grady, John M.; Van Conett, Linda A.; Hall, Mary B.; Soltau, Joern B.; Mohay, Judit; Shrader, Robb R.; Lear, Sandy; Herman, David C.; Johnson, Douglas H.; Nielsen, Becky A.; Tvedt, Nancy J.; Liebmann, Jeffrey M.; Ritch, Robert; Tello, Celso A.; Walker, Jean L.; Mondoc, Nina C.; Simon, Deborah L.; Weber, Paul; Baker, N. Douglas; Derick, Robert J.; Lehmann, David; McKinney, Kathyrne; Moore, Diane; Bennett, G. Richard; Yanoff, Myron; Bennett, Lindsay C.; Jameson, Mary; Piltz-Seymour, Jody R.; Ahmed, Hina N.; Miller, Eydie G.; Sankar, Prithvi S.; McGill, Cheryl; Petner, Janice T.; Brandt, James D.; Casper, Jeffrey J.; Lim, Michele C.; Schwab, Ivan R.; Clark, Ingrid J.; Owensby, Denise M.; Sponzo, Marilyn A.; Weinreb, Robert N.; Slight, J. Rigby; Okuonghae, Osaro A.; Drake, Michael V.; Flach, Allan J.; Lin, Shan C.; Stamper, Robert; Ballesteros, Fermin P.; Margol, Valerie; Lamping, Kathleen A.; Vitelli, Cheryl L.; Modica, Bettina J.; Gaasterland, Douglas E.; Montgomery, Robin L.; Ashburn, Frank S.; Schacht, Karen D.; Schwartz, Arthur L.; Weiss, Howard S.; Clark, Clete; Boeckl, Anne M.; Barnett, Edward M.; Becker, Bernard; Bhorade, Anjali M.; Kolker, Allan E.; Siegfried, Carla J.; Quirin, Sandra; Darmody, Fortunata; Anderson, Douglas R.; Everett, Donald F.; Gordon, Mae E.; Heuer, Dale K.; Keltner, John A.; Wilson, M. Roy; Morris, Patricia A.; Roediger, Teresa A.; Connett, John; Cowan, Claude; Davis, Barry; Katz, Jo Anne; Munson, Ronald; Sherwood, Mark; Skuta, Gregory L.; Heur, Dale K.; Kymes, Steven; Miller, J. Philip; Bednarski, Mary; Beiser, Julia; Clark, Karen; Hornbeck, Betsy; Long, Ellen; Dunn, Deborah; Wells-Albornoz, Maria Cristina; Vandenbroucke, Ruth; Johnson, Heather; Feuer, William; Schiffman, Joyce; Hess, Ditte; Cello, Kimberly E.; Bandermann, Shannan E.; Dhillon, Bhupinder S.; Zangwill, Linda; Dirkes, Keri; Sample, Pamela A.; Bourne, William M.
In: Investigative Ophthalmology and Visual Science, Vol. 47, No. 9, 09.2006, p. 3896-3903.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study
AU - Levine, Richard A.
AU - Demirel, Shaban
AU - Fan, Juanjuan
AU - Keltner, John L.
AU - Johnson, Chris A.
AU - Kass, Michael A.
AU - Budenz, Donald L.
AU - Fantes, Francisco E.
AU - Gedde, Steven J.
AU - Parrish, Richard K.
AU - Del Calvo, Madeline L.
AU - Harbin, Thomas S.
AU - McManus, Paul
AU - Patorgis, Charles J.
AU - Hooper, Montana L.
AU - Goldstein, Stacey S.
AU - Lee, Debbie L.
AU - Morton, Lea
AU - Perry, Marianne L.
AU - Long, Teresa A.
AU - Smith, Shelly R.
AU - Wright, Julie M.
AU - Gross, Ronald L.
AU - Orengo-Nania, Silvia
AU - Frady, Pamela M.
AU - Slight, Benita D.
AU - Cioffi, George A.
AU - Jamil, Annisa L.
AU - Mansberger, Steven
AU - Patterson, Emily L.
AU - Sherman, Kathryn
AU - Fraser, Jo Anne M.
AU - Beck, Allen D.
AU - Costarides, Anastasias
AU - Hylton, Camilele M.
AU - Leef, Donna
AU - Imami, Nauman R.
AU - Darnley-Fisch, Deborah
AU - Fantin, Aldo
AU - Gutkowski, Melanie
AU - Carnegie, Elizabeth
AU - Rock, Sheila
AU - Zack, Donald J.
AU - Abrams, Donald A.
AU - Congdon, Nathan G.
AU - Copeland, Robert A.
AU - Friedman, David S.
AU - Hemady, Ramzi
AU - Higginbotham, Eve J.
AU - Jampel, Henry D.
AU - Pollack, Irvin P.
AU - Quigley, Harry A.
AU - Robin, Alan L.
AU - Scott, Rachel
AU - Keel, Felicia
AU - Levin, Lisa
AU - Powdrill, Kevin L.
AU - Priest-Reed, Robyn
AU - Coleman, Anne L.
AU - Baker, Richard S.
AU - Dang, Y. P.
AU - Giaconi, Jo Ann A.
AU - Law, Simon K.
AU - Ballenberg, Bobbie
AU - Murillo, Salvador
AU - Sharma, Manju
AU - Bergstrom, Terry J.
AU - Bruno, Christina A.
AU - Moroi, Sayoko E.
AU - Pollack-Rundle, Carol J.
AU - Tehranisa, Michelle A.
AU - Hughes, Bret A.
AU - Allen, Monica Y.
AU - Juzych, Mark S.
AU - McDermott, Mark L.
AU - Ramocki, John M.
AU - Allen, Juan
AU - Schulz, Laura L.
AU - O'Grady, John M.
AU - Van Conett, Linda A.
AU - Hall, Mary B.
AU - Soltau, Joern B.
AU - Mohay, Judit
AU - Shrader, Robb R.
AU - Lear, Sandy
AU - Herman, David C.
AU - Johnson, Douglas H.
AU - Nielsen, Becky A.
AU - Tvedt, Nancy J.
AU - Liebmann, Jeffrey M.
AU - Ritch, Robert
AU - Tello, Celso A.
AU - Walker, Jean L.
AU - Mondoc, Nina C.
AU - Simon, Deborah L.
AU - Weber, Paul
AU - Baker, N. Douglas
AU - Derick, Robert J.
AU - Lehmann, David
AU - McKinney, Kathyrne
AU - Moore, Diane
AU - Bennett, G. Richard
AU - Yanoff, Myron
AU - Bennett, Lindsay C.
AU - Jameson, Mary
AU - Piltz-Seymour, Jody R.
AU - Ahmed, Hina N.
AU - Miller, Eydie G.
AU - Sankar, Prithvi S.
AU - McGill, Cheryl
AU - Petner, Janice T.
AU - Brandt, James D.
AU - Casper, Jeffrey J.
AU - Lim, Michele C.
AU - Schwab, Ivan R.
AU - Clark, Ingrid J.
AU - Owensby, Denise M.
AU - Sponzo, Marilyn A.
AU - Weinreb, Robert N.
AU - Slight, J. Rigby
AU - Okuonghae, Osaro A.
AU - Drake, Michael V.
AU - Flach, Allan J.
AU - Lin, Shan C.
AU - Stamper, Robert
AU - Ballesteros, Fermin P.
AU - Margol, Valerie
AU - Lamping, Kathleen A.
AU - Vitelli, Cheryl L.
AU - Modica, Bettina J.
AU - Gaasterland, Douglas E.
AU - Montgomery, Robin L.
AU - Ashburn, Frank S.
AU - Schacht, Karen D.
AU - Schwartz, Arthur L.
AU - Weiss, Howard S.
AU - Clark, Clete
AU - Boeckl, Anne M.
AU - Barnett, Edward M.
AU - Becker, Bernard
AU - Bhorade, Anjali M.
AU - Kolker, Allan E.
AU - Siegfried, Carla J.
AU - Quirin, Sandra
AU - Darmody, Fortunata
AU - Anderson, Douglas R.
AU - Everett, Donald F.
AU - Gordon, Mae E.
AU - Heuer, Dale K.
AU - Keltner, John A.
AU - Wilson, M. Roy
AU - Morris, Patricia A.
AU - Roediger, Teresa A.
AU - Connett, John
AU - Cowan, Claude
AU - Davis, Barry
AU - Katz, Jo Anne
AU - Munson, Ronald
AU - Sherwood, Mark
AU - Skuta, Gregory L.
AU - Heur, Dale K.
AU - Kymes, Steven
AU - Miller, J. Philip
AU - Bednarski, Mary
AU - Beiser, Julia
AU - Clark, Karen
AU - Hornbeck, Betsy
AU - Long, Ellen
AU - Dunn, Deborah
AU - Wells-Albornoz, Maria Cristina
AU - Vandenbroucke, Ruth
AU - Johnson, Heather
AU - Feuer, William
AU - Schiffman, Joyce
AU - Hess, Ditte
AU - Cello, Kimberly E.
AU - Bandermann, Shannan E.
AU - Dhillon, Bhupinder S.
AU - Zangwill, Linda
AU - Dirkes, Keri
AU - Sample, Pamela A.
AU - Bourne, William M.
N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/9
Y1 - 2006/9
N2 - PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.
AB - PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.
UR - http://www.scopus.com/inward/record.url?scp=33749158039&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749158039&partnerID=8YFLogxK
U2 - 10.1167/iovs.05-0469
DO - 10.1167/iovs.05-0469
M3 - Article
C2 - 16936102
AN - SCOPUS:33749158039
VL - 47
SP - 3896
EP - 3903
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
SN - 0146-0404
IS - 9
ER -