Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study

Richard A. Levine; Shaban Demirel; Juanjuan Fan; John L. Keltner; Chris A. Johnson; Michael A. Kass; Donald L. Budenz; Francisco E. Fantes; Steven J. Gedde; Richard K. Parrish; Madeline L. Del Calvo; Thomas S. Harbin; Paul McManus; Charles J. Patorgis; Montana L. Hooper; Stacey S. Goldstein; Debbie L. Lee; Lea Morton; Marianne L. Perry; Teresa A. Long; Shelly R. Smith; Julie M. Wright; Ronald L. Gross; Silvia Orengo-Nania; Pamela M. Frady; Benita D. Slight; George A. Cioffi; Annisa L. Jamil; Steven Mansberger; Emily L. Patterson; Kathryn Sherman; Jo Anne M. Fraser; Allen D. Beck; Anastasias Costarides; Camilele M. Hylton; Donna Leef; Nauman R. Imami; Deborah Darnley-Fisch; Aldo Fantin; Melanie Gutkowski; Elizabeth Carnegie; Sheila Rock; Donald J. Zack; Donald A. Abrams; Nathan G. Congdon; Robert A. Copeland; David S. Friedman; Ramzi Hemady; Eve J. Higginbotham; Henry D. Jampel; Irvin P. Pollack; Harry A. Quigley; Alan L. Robin; Rachel Scott; Felicia Keel; Lisa Levin; Kevin L. Powdrill; Robyn Priest-Reed; Anne L. Coleman; Richard S. Baker; Y. P. Dang; Jo Ann A. Giaconi; Simon K. Law; Bobbie Ballenberg; Salvador Murillo; Manju Sharma; Terry J. Bergstrom; Christina A. Bruno; Sayoko E. Moroi; Carol J. Pollack-Rundle; Michelle A. Tehranisa; Bret A. Hughes; Monica Y. Allen; Mark S. Juzych; Mark L. McDermott; John M. Ramocki; Juan Allen; Laura L. Schulz; John M. O'Grady; Linda A. Van Conett; Mary B. Hall; Joern B. Soltau; Judit Mohay; Robb R. Shrader; Sandy Lear; David C. Herman; Douglas H. Johnson; Becky A. Nielsen; Nancy J. Tvedt; Jeffrey M. Liebmann; Robert Ritch; Celso A. Tello; Jean L. Walker; Nina C. Mondoc; Deborah L. Simon; Paul Weber; N. Douglas Baker; Robert J. Derick; David Lehmann; Kathyrne McKinney; Diane Moore; G. Richard Bennett; Myron Yanoff; Lindsay C. Bennett; Mary Jameson; Jody R. Piltz-Seymour; Hina N. Ahmed; Eydie G. Miller; Prithvi S. Sankar; Cheryl McGill; Janice T. Petner; James D. Brandt; Jeffrey J. Casper; Michele C. Lim; Ivan R. Schwab; Ingrid J. Clark; Denise M. Owensby; Marilyn A. Sponzo; Robert N. Weinreb; J. Rigby Slight; Osaro A. Okuonghae; Michael V. Drake; Allan J. Flach; Shan C. Lin; Robert Stamper; Fermin P. Ballesteros; Valerie Margol; Kathleen A. Lamping; Cheryl L. Vitelli; Bettina J. Modica; Douglas E. Gaasterland; Robin L. Montgomery; Frank S. Ashburn; Karen D. Schacht; Arthur L. Schwartz; Howard S. Weiss; Clete Clark; Anne M. Boeckl; Edward M. Barnett; Bernard Becker; Anjali M. Bhorade; Allan E. Kolker; Carla J. Siegfried; Sandra Quirin; Fortunata Darmody; Douglas R. Anderson; Donald F. Everett; Mae E. Gordon; Dale K. Heuer; John A. Keltner; M. Roy Wilson; Patricia A. Morris; Teresa A. Roediger; John Connett; Claude Cowan; Barry Davis; Jo Anne Katz; Ronald Munson; Mark Sherwood; Gregory L. Skuta; Dale K. Heur; Steven Kymes; J. Philip Miller; Mary Bednarski; Julia Beiser; Karen Clark; Betsy Hornbeck; Ellen Long; Deborah Dunn; Maria Cristina Wells-Albornoz; Ruth Vandenbroucke; Heather Johnson; William Feuer; Joyce Schiffman; Ditte Hess; Kimberly E. Cello; Shannan E. Bandermann; Bhupinder S. Dhillon; Linda Zangwill; Keri Dirkes; Pamela A. Sample; William M. Bourne

doi:10.1167/iovs.05-0469

Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study

Richard A. Levine, Shaban Demirel, Juanjuan Fan, John L. Keltner, Chris A. Johnson, Michael A. Kass, Donald L. Budenz, Francisco E. Fantes, Steven J. Gedde, Richard K. Parrish, Madeline L. Del Calvo, Thomas S. Harbin, Paul McManus, Charles J. Patorgis, Montana L. Hooper, Stacey S. Goldstein, Debbie L. Lee, Lea Morton, Marianne L. Perry, Teresa A. LongShelly R. Smith, Julie M. Wright, Ronald L. Gross, Silvia Orengo-Nania, Pamela M. Frady, Benita D. Slight, George A. Cioffi, Annisa L. Jamil, Steven Mansberger, Emily L. Patterson, Kathryn Sherman, Jo Anne M. Fraser, Allen D. Beck, Anastasias Costarides, Camilele M. Hylton, Donna Leef, Nauman R. Imami, Deborah Darnley-Fisch, Aldo Fantin, Melanie Gutkowski, Elizabeth Carnegie, Sheila Rock, Donald J. Zack, Donald A. Abrams, Nathan G. Congdon, Robert A. Copeland, David S. Friedman, Ramzi Hemady, Eve J. Higginbotham, Henry D. Jampel, Irvin P. Pollack, Harry A. Quigley, Alan L. Robin, Rachel Scott, Felicia Keel, Lisa Levin, Kevin L. Powdrill, Robyn Priest-Reed, Anne L. Coleman, Richard S. Baker, Y. P. Dang, Jo Ann A. Giaconi, Simon K. Law, Bobbie Ballenberg, Salvador Murillo, Manju Sharma, Terry J. Bergstrom, Christina A. Bruno, Sayoko E. Moroi, Carol J. Pollack-Rundle, Michelle A. Tehranisa, Bret A. Hughes, Monica Y. Allen, Mark S. Juzych, Mark L. McDermott, John M. Ramocki, Juan Allen, Laura L. Schulz, John M. O'Grady, Linda A. Van Conett, Mary B. Hall, Joern B. Soltau, Judit Mohay, Robb R. Shrader, Sandy Lear, David C. Herman, Douglas H. Johnson, Becky A. Nielsen, Nancy J. Tvedt, Jeffrey M. Liebmann, Robert Ritch, Celso A. Tello, Jean L. Walker, Nina C. Mondoc, Deborah L. Simon, Paul Weber, N. Douglas Baker, Robert J. Derick, David Lehmann, Kathyrne McKinney, Diane Moore, G. Richard Bennett, Myron Yanoff, Lindsay C. Bennett, Mary Jameson, Jody R. Piltz-Seymour, Hina N. Ahmed, Eydie G. Miller, Prithvi S. Sankar, Cheryl McGill, Janice T. Petner, James D. Brandt, Jeffrey J. Casper, Michele C. Lim, Ivan R. Schwab, Ingrid J. Clark, Denise M. Owensby, Marilyn A. Sponzo, Robert N. Weinreb, J. Rigby Slight, Osaro A. Okuonghae, Michael V. Drake, Allan J. Flach, Shan C. Lin, Robert Stamper, Fermin P. Ballesteros, Valerie Margol, Kathleen A. Lamping, Cheryl L. Vitelli, Bettina J. Modica, Douglas E. Gaasterland, Robin L. Montgomery, Frank S. Ashburn, Karen D. Schacht, Arthur L. Schwartz, Howard S. Weiss, Clete Clark, Anne M. Boeckl, Edward M. Barnett, Bernard Becker, Anjali M. Bhorade, Allan E. Kolker, Carla J. Siegfried, Sandra Quirin, Fortunata Darmody, Douglas R. Anderson, Donald F. Everett, Mae E. Gordon, Dale K. Heuer, John A. Keltner, M. Roy Wilson, Patricia A. Morris, Teresa A. Roediger, John Connett, Claude Cowan, Barry Davis, Jo Anne Katz, Ronald Munson, Mark Sherwood, Gregory L. Skuta, Dale K. Heur, Steven Kymes, J. Philip Miller, Mary Bednarski, Julia Beiser, Karen Clark, Betsy Hornbeck, Ellen Long, Deborah Dunn, Maria Cristina Wells-Albornoz, Ruth Vandenbroucke, Heather Johnson, William Feuer, Joyce Schiffman, Ditte Hess, Kimberly E. Cello, Shannan E. Bandermann, Bhupinder S. Dhillon, Linda Zangwill, Keri Dirkes, Pamela A. Sample, William M. Bourne

Research output: Contribution to journal › Article › peer-review

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Abstract

PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.

Original language	English (US)
Pages (from-to)	3896-3903
Number of pages	8
Journal	Investigative Ophthalmology and Visual Science
Volume	47
Issue number	9
DOIs	https://doi.org/10.1167/iovs.05-0469
State	Published - Sep 2006

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Levine, R. A., Demirel, S., Fan, J., Keltner, J. L., Johnson, C. A., Kass, M. A., Budenz, D. L., Fantes, F. E., Gedde, S. J., Parrish, R. K., Del Calvo, M. L., Harbin, T. S., McManus, P., Patorgis, C. J., Hooper, M. L., Goldstein, S. S., Lee, D. L., Morton, L., Perry, M. L., ... Bourne, W. M. (2006). Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study. Investigative Ophthalmology and Visual Science, 47(9), 3896-3903. https://doi.org/10.1167/iovs.05-0469

Levine, RA, Demirel, S, Fan, J, Keltner, JL, Johnson, CA, Kass, MA, Budenz, DL, Fantes, FE, Gedde, SJ, Parrish, RK, Del Calvo, ML, Harbin, TS, McManus, P, Patorgis, CJ, Hooper, ML, Goldstein, SS, Lee, DL, Morton, L, Perry, ML, Long, TA, Smith, SR, Wright, JM, Gross, RL, Orengo-Nania, S, Frady, PM, Slight, BD, Cioffi, GA, Jamil, AL, Mansberger, S, Patterson, EL, Sherman, K, Fraser, JAM, Beck, AD, Costarides, A, Hylton, CM, Leef, D, Imami, NR, Darnley-Fisch, D, Fantin, A, Gutkowski, M, Carnegie, E, Rock, S, Zack, DJ, Abrams, DA, Congdon, NG, Copeland, RA, Friedman, DS, Hemady, R, Higginbotham, EJ, Jampel, HD, Pollack, IP, Quigley, HA, Robin, AL, Scott, R, Keel, F, Levin, L, Powdrill, KL, Priest-Reed, R, Coleman, AL, Baker, RS, Dang, YP, Giaconi, JAA, Law, SK, Ballenberg, B, Murillo, S, Sharma, M, Bergstrom, TJ, Bruno, CA, Moroi, SE, Pollack-Rundle, CJ, Tehranisa, MA, Hughes, BA, Allen, MY, Juzych, MS, McDermott, ML, Ramocki, JM, Allen, J, Schulz, LL, O'Grady, JM, Van Conett, LA, Hall, MB, Soltau, JB, Mohay, J, Shrader, RR, Lear, S, Herman, DC, Johnson, DH, Nielsen, BA, Tvedt, NJ, Liebmann, JM, Ritch, R, Tello, CA, Walker, JL, Mondoc, NC, Simon, DL, Weber, P, Baker, ND, Derick, RJ, Lehmann, D, McKinney, K, Moore, D, Bennett, GR, Yanoff, M, Bennett, LC, Jameson, M, Piltz-Seymour, JR, Ahmed, HN, Miller, EG, Sankar, PS, McGill, C, Petner, JT, Brandt, JD, Casper, JJ, Lim, MC, Schwab, IR, Clark, IJ, Owensby, DM, Sponzo, MA, Weinreb, RN, Slight, JR, Okuonghae, OA, Drake, MV, Flach, AJ, Lin, SC, Stamper, R, Ballesteros, FP, Margol, V, Lamping, KA, Vitelli, CL, Modica, BJ, Gaasterland, DE, Montgomery, RL, Ashburn, FS, Schacht, KD, Schwartz, AL, Weiss, HS, Clark, C, Boeckl, AM, Barnett, EM, Becker, B, Bhorade, AM, Kolker, AE, Siegfried, CJ, Quirin, S, Darmody, F, Anderson, DR, Everett, DF, Gordon, ME, Heuer, DK, Keltner, JA, Wilson, MR, Morris, PA, Roediger, TA, Connett, J, Cowan, C, Davis, B, Katz, JA, Munson, R, Sherwood, M, Skuta, GL, Heur, DK, Kymes, S, Miller, JP, Bednarski, M, Beiser, J, Clark, K, Hornbeck, B, Long, E, Dunn, D, Wells-Albornoz, MC, Vandenbroucke, R, Johnson, H, Feuer, W, Schiffman, J, Hess, D, Cello, KE, Bandermann, SE, Dhillon, BS, Zangwill, L, Dirkes, K, Sample, PA & Bourne, WM 2006, 'Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study', Investigative Ophthalmology and Visual Science, vol. 47, no. 9, pp. 3896-3903. https://doi.org/10.1167/iovs.05-0469

@article{addc62d7e63f4286a603edfb8104358c,

title = "Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study",

abstract = "PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.",

author = "Levine, {Richard A.} and Shaban Demirel and Juanjuan Fan and Keltner, {John L.} and Johnson, {Chris A.} and Kass, {Michael A.} and Budenz, {Donald L.} and Fantes, {Francisco E.} and Gedde, {Steven J.} and Parrish, {Richard K.} and {Del Calvo}, {Madeline L.} and Harbin, {Thomas S.} and Paul McManus and Patorgis, {Charles J.} and Hooper, {Montana L.} and Goldstein, {Stacey S.} and Lee, {Debbie L.} and Lea Morton and Perry, {Marianne L.} and Long, {Teresa A.} and Smith, {Shelly R.} and Wright, {Julie M.} and Gross, {Ronald L.} and Silvia Orengo-Nania and Frady, {Pamela M.} and Slight, {Benita D.} and Cioffi, {George A.} and Jamil, {Annisa L.} and Steven Mansberger and Patterson, {Emily L.} and Kathryn Sherman and Fraser, {Jo Anne M.} and Beck, {Allen D.} and Anastasias Costarides and Hylton, {Camilele M.} and Donna Leef and Imami, {Nauman R.} and Deborah Darnley-Fisch and Aldo Fantin and Melanie Gutkowski and Elizabeth Carnegie and Sheila Rock and Zack, {Donald J.} and Abrams, {Donald A.} and Congdon, {Nathan G.} and Copeland, {Robert A.} and Friedman, {David S.} and Ramzi Hemady and Higginbotham, {Eve J.} and Jampel, {Henry D.} and Pollack, {Irvin P.} and Quigley, {Harry A.} and Robin, {Alan L.} and Rachel Scott and Felicia Keel and Lisa Levin and Powdrill, {Kevin L.} and Robyn Priest-Reed and Coleman, {Anne L.} and Baker, {Richard S.} and Dang, {Y. P.} and Giaconi, {Jo Ann A.} and Law, {Simon K.} and Bobbie Ballenberg and Salvador Murillo and Manju Sharma and Bergstrom, {Terry J.} and Bruno, {Christina A.} and Moroi, {Sayoko E.} and Pollack-Rundle, {Carol J.} and Tehranisa, {Michelle A.} and Hughes, {Bret A.} and Allen, {Monica Y.} and Juzych, {Mark S.} and McDermott, {Mark L.} and Ramocki, {John M.} and Juan Allen and Schulz, {Laura L.} and O'Grady, {John M.} and {Van Conett}, {Linda A.} and Hall, {Mary B.} and Soltau, {Joern B.} and Judit Mohay and Shrader, {Robb R.} and Sandy Lear and Herman, {David C.} and Johnson, {Douglas H.} and Nielsen, {Becky A.} and Tvedt, {Nancy J.} and Liebmann, {Jeffrey M.} and Robert Ritch and Tello, {Celso A.} and Walker, {Jean L.} and Mondoc, {Nina C.} and Simon, {Deborah L.} and Paul Weber and Baker, {N. Douglas} and Derick, {Robert J.} and David Lehmann and Kathyrne McKinney and Diane Moore and Bennett, {G. Richard} and Myron Yanoff and Bennett, {Lindsay C.} and Mary Jameson and Piltz-Seymour, {Jody R.} and Ahmed, {Hina N.} and Miller, {Eydie G.} and Sankar, {Prithvi S.} and Cheryl McGill and Petner, {Janice T.} and Brandt, {James D.} and Casper, {Jeffrey J.} and Lim, {Michele C.} and Schwab, {Ivan R.} and Clark, {Ingrid J.} and Owensby, {Denise M.} and Sponzo, {Marilyn A.} and Weinreb, {Robert N.} and Slight, {J. Rigby} and Okuonghae, {Osaro A.} and Drake, {Michael V.} and Flach, {Allan J.} and Lin, {Shan C.} and Robert Stamper and Ballesteros, {Fermin P.} and Valerie Margol and Lamping, {Kathleen A.} and Vitelli, {Cheryl L.} and Modica, {Bettina J.} and Gaasterland, {Douglas E.} and Montgomery, {Robin L.} and Ashburn, {Frank S.} and Schacht, {Karen D.} and Schwartz, {Arthur L.} and Weiss, {Howard S.} and Clete Clark and Boeckl, {Anne M.} and Barnett, {Edward M.} and Bernard Becker and Bhorade, {Anjali M.} and Kolker, {Allan E.} and Siegfried, {Carla J.} and Sandra Quirin and Fortunata Darmody and Anderson, {Douglas R.} and Everett, {Donald F.} and Gordon, {Mae E.} and Heuer, {Dale K.} and Keltner, {John A.} and Wilson, {M. Roy} and Morris, {Patricia A.} and Roediger, {Teresa A.} and John Connett and Claude Cowan and Barry Davis and Katz, {Jo Anne} and Ronald Munson and Mark Sherwood and Skuta, {Gregory L.} and Heur, {Dale K.} and Steven Kymes and Miller, {J. Philip} and Mary Bednarski and Julia Beiser and Karen Clark and Betsy Hornbeck and Ellen Long and Deborah Dunn and Wells-Albornoz, {Maria Cristina} and Ruth Vandenbroucke and Heather Johnson and William Feuer and Joyce Schiffman and Ditte Hess and Cello, {Kimberly E.} and Bandermann, {Shannan E.} and Dhillon, {Bhupinder S.} and Linda Zangwill and Keri Dirkes and Sample, {Pamela A.} and Bourne, {William M.}",

year = "2006",

month = sep,

doi = "10.1167/iovs.05-0469",

language = "English (US)",

volume = "47",

pages = "3896--3903",

journal = "Investigative Ophthalmology and Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology Inc.",

number = "9",

}

TY - JOUR

T1 - Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study

AU - Levine, Richard A.

AU - Demirel, Shaban

AU - Fan, Juanjuan

AU - Keltner, John L.

AU - Johnson, Chris A.

AU - Kass, Michael A.

AU - Budenz, Donald L.

AU - Fantes, Francisco E.

AU - Gedde, Steven J.

AU - Parrish, Richard K.

AU - Del Calvo, Madeline L.

AU - Harbin, Thomas S.

AU - McManus, Paul

AU - Patorgis, Charles J.

AU - Hooper, Montana L.

AU - Goldstein, Stacey S.

AU - Lee, Debbie L.

AU - Morton, Lea

AU - Perry, Marianne L.

AU - Long, Teresa A.

AU - Smith, Shelly R.

AU - Wright, Julie M.

AU - Gross, Ronald L.

AU - Orengo-Nania, Silvia

AU - Frady, Pamela M.

AU - Slight, Benita D.

AU - Cioffi, George A.

AU - Jamil, Annisa L.

AU - Mansberger, Steven

AU - Patterson, Emily L.

AU - Sherman, Kathryn

AU - Fraser, Jo Anne M.

AU - Beck, Allen D.

AU - Costarides, Anastasias

AU - Hylton, Camilele M.

AU - Leef, Donna

AU - Imami, Nauman R.

AU - Darnley-Fisch, Deborah

AU - Fantin, Aldo

AU - Gutkowski, Melanie

AU - Carnegie, Elizabeth

AU - Rock, Sheila

AU - Zack, Donald J.

AU - Abrams, Donald A.

AU - Congdon, Nathan G.

AU - Copeland, Robert A.

AU - Friedman, David S.

AU - Hemady, Ramzi

AU - Higginbotham, Eve J.

AU - Jampel, Henry D.

AU - Pollack, Irvin P.

AU - Quigley, Harry A.

AU - Robin, Alan L.

AU - Scott, Rachel

AU - Keel, Felicia

AU - Levin, Lisa

AU - Powdrill, Kevin L.

AU - Priest-Reed, Robyn

AU - Coleman, Anne L.

AU - Baker, Richard S.

AU - Dang, Y. P.

AU - Giaconi, Jo Ann A.

AU - Law, Simon K.

AU - Ballenberg, Bobbie

AU - Murillo, Salvador

AU - Sharma, Manju

AU - Bergstrom, Terry J.

AU - Bruno, Christina A.

AU - Moroi, Sayoko E.

AU - Pollack-Rundle, Carol J.

AU - Tehranisa, Michelle A.

AU - Hughes, Bret A.

AU - Allen, Monica Y.

AU - Juzych, Mark S.

AU - McDermott, Mark L.

AU - Ramocki, John M.

AU - Allen, Juan

AU - Schulz, Laura L.

AU - O'Grady, John M.

AU - Van Conett, Linda A.

AU - Hall, Mary B.

AU - Soltau, Joern B.

AU - Mohay, Judit

AU - Shrader, Robb R.

AU - Lear, Sandy

AU - Herman, David C.

AU - Johnson, Douglas H.

AU - Nielsen, Becky A.

AU - Tvedt, Nancy J.

AU - Liebmann, Jeffrey M.

AU - Ritch, Robert

AU - Tello, Celso A.

AU - Walker, Jean L.

AU - Mondoc, Nina C.

AU - Simon, Deborah L.

AU - Weber, Paul

AU - Baker, N. Douglas

AU - Derick, Robert J.

AU - Lehmann, David

AU - McKinney, Kathyrne

AU - Moore, Diane

AU - Bennett, G. Richard

AU - Yanoff, Myron

AU - Bennett, Lindsay C.

AU - Jameson, Mary

AU - Piltz-Seymour, Jody R.

AU - Ahmed, Hina N.

AU - Miller, Eydie G.

AU - Sankar, Prithvi S.

AU - McGill, Cheryl

AU - Petner, Janice T.

AU - Brandt, James D.

AU - Casper, Jeffrey J.

AU - Lim, Michele C.

AU - Schwab, Ivan R.

AU - Clark, Ingrid J.

AU - Owensby, Denise M.

AU - Sponzo, Marilyn A.

AU - Weinreb, Robert N.

AU - Slight, J. Rigby

AU - Okuonghae, Osaro A.

AU - Drake, Michael V.

AU - Flach, Allan J.

AU - Lin, Shan C.

AU - Stamper, Robert

AU - Ballesteros, Fermin P.

AU - Margol, Valerie

AU - Lamping, Kathleen A.

AU - Vitelli, Cheryl L.

AU - Modica, Bettina J.

AU - Gaasterland, Douglas E.

AU - Montgomery, Robin L.

AU - Ashburn, Frank S.

AU - Schacht, Karen D.

AU - Schwartz, Arthur L.

AU - Weiss, Howard S.

AU - Clark, Clete

AU - Boeckl, Anne M.

AU - Barnett, Edward M.

AU - Becker, Bernard

AU - Bhorade, Anjali M.

AU - Kolker, Allan E.

AU - Siegfried, Carla J.

AU - Quirin, Sandra

AU - Darmody, Fortunata

AU - Anderson, Douglas R.

AU - Everett, Donald F.

AU - Gordon, Mae E.

AU - Heuer, Dale K.

AU - Keltner, John A.

AU - Wilson, M. Roy

AU - Morris, Patricia A.

AU - Roediger, Teresa A.

AU - Connett, John

AU - Cowan, Claude

AU - Davis, Barry

AU - Katz, Jo Anne

AU - Munson, Ronald

AU - Sherwood, Mark

AU - Skuta, Gregory L.

AU - Heur, Dale K.

AU - Kymes, Steven

AU - Miller, J. Philip

AU - Bednarski, Mary

AU - Beiser, Julia

AU - Clark, Karen

AU - Hornbeck, Betsy

AU - Long, Ellen

AU - Dunn, Deborah

AU - Wells-Albornoz, Maria Cristina

AU - Vandenbroucke, Ruth

AU - Johnson, Heather

AU - Feuer, William

AU - Schiffman, Joyce

AU - Hess, Ditte

AU - Cello, Kimberly E.

AU - Bandermann, Shannan E.

AU - Dhillon, Bhupinder S.

AU - Zangwill, Linda

AU - Dirkes, Keri

AU - Sample, Pamela A.

AU - Bourne, William M.

PY - 2006/9

Y1 - 2006/9

N2 - PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.

AB - PURPOSE. To evaluate whether baseline visual field data and asymmetries between eyes predict the onset of primary open-angle glaucoma (POAG) in Ocular Hypertension Treatment Study (OHTS) participants. METHODS. A new index, mean prognosis (MP), was designed for optimal combination of visual field thresholds, to discriminate between eyes that developed POAG from eyes that did not. Baseline intraocular pressure (IOP) in fellow eyes was used to construct measures of IOP asymmetry. Age-adjusted baseline thresholds were used to develop indicators of visual field asymmetry and summary measures of visual field defects. Marginal multivariate failure time models were constructed that relate the new index MP, IOP asymmetry, and visual field asymmetry to POAG onset for OHTS participants. RESULTS. The marginal multivariate failure time analysis showed that the MP index is significantly related to POAG onset (P < 0.0001) and appears to be a more highly significant predictor of POAG onset than either mean deviation (MD; P = 0.17) or pattern standard deviation (PSD; P = 0.046). A 1-mm Hg increase in IOP asymmetry between fellow eyes is associated with a 17% increase in risk for development of POAG. When threshold asymmetry between eyes existed, the eye with lower thresholds was at a 37% greater risk of development of POAG, and this feature was more predictive of POAG onset than the visual field index MD, though not as strong a predictor as PSD. CONCLUSIONS. The MP index, IOP asymmetry, and binocular test point asymmetry can assist in clinical evaluation of eyes at risk of development of POAG.

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U2 - 10.1167/iovs.05-0469

DO - 10.1167/iovs.05-0469

M3 - Article

C2 - 16936102

AN - SCOPUS:33749158039

SN - 0146-0404

VL - 47

SP - 3896

EP - 3903

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 9

ER -

Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study

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