Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)

James Drewett, Gary Marchand, Richard Ziegler, George J Trachte

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalEuropean Journal of Pharmacology
Volume150
Issue number1-2
DOIs
StatePublished - May 20 1988

Keywords

  • (Cell-line)
  • Atrial natriuretic factor (ANF)
  • Norepinephrine
  • Pheochromocytoma cells (PC12)
  • Sympathetic nervous system

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