TY - JOUR
T1 - Atrial natriuretic factor inhibits norepinephrine release in an adrenergic clonal cell line (PC12)
AU - Drewett, James
AU - Marchand, Gary
AU - Ziegler, Richard
AU - Trachte, George J
PY - 1988/5/20
Y1 - 1988/5/20
N2 - Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.
AB - Evidence for a presynaptic neuromodulatory effect of atrial natriuretic factor (ANF) has been obtained in rat adrenal pheochromocytoma cells (PC12), a clonal line that differentiates into adrenergic neuron-like cells when treated with nerve growth factor. ANF had no effect on basal norepinephrine (NE) release. In contrast, ANF markedly and significantly inhibited carbachol-induced NE release in a concentration-dependent manner. This result is consistent with the hypothesis that ANF may be an inhibitory neuromodulator.
KW - (Cell-line)
KW - Atrial natriuretic factor (ANF)
KW - Norepinephrine
KW - Pheochromocytoma cells (PC12)
KW - Sympathetic nervous system
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U2 - 10.1016/0014-2999(88)90765-0
DO - 10.1016/0014-2999(88)90765-0
M3 - Article
C2 - 2969821
AN - SCOPUS:0023907429
VL - 150
SP - 175
EP - 179
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1-2
ER -