Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories

William E. Semple, Peter F. Goyer, Richard McCormick, Beth Compton-Toth, Evan Morris, Beverly Donovan, Gary Muswick, Dennis Nelson, Michelle L. Garnett, James Sharkoff, Greg Leisure, Floro Miraldi, S. Charles Schulz

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80 Scopus citations

Abstract

Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with 15O-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD.

Original languageEnglish (US)
Pages (from-to)17-28
Number of pages12
JournalPsychiatry Research - Neuroimaging
Volume67
Issue number1
DOIs
StatePublished - May 31 1996

Keywords

  • Continuous performance task
  • Parietal cortex
  • Positron emission tomography

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