TY - JOUR
T1 - Attention-deficit/hyperactivity disorder
T2 - A preliminary diffusion tensor imaging study
AU - Ashtari, Manzar
AU - Kumra, Sanjiv
AU - Bhaskar, Shree L.
AU - Clarke, Tana
AU - Thaden, Emily
AU - Cervellione, Kelly L.
AU - Rhinewine, Joseph
AU - Kane, John M.
AU - Adesman, Andrew
AU - Milanaik, Ruth
AU - Maytal, Joseph
AU - Diamond, Alan
AU - Szeszko, Philip
AU - Ardekani, Babak A.
PY - 2005/3/1
Y1 - 2005/3/1
N2 - Background: The purpose of this study was to explore whether there are white matter (WM) abnormalities in children with attention-deficit/hyperactivity disorder (ADHD) using diffusion tensor imaging. Based upon the literature, we predicted decreased fractional anisotropy (FA) findings in the frontal and cerebellar regions. Methods: Eighteen patients with ADHD and 15 age- and gender-matched healthy volunteers received DTI assessments. Fractional anisotropy maps of WM were compared between groups with a voxelwise analysis after intersubject registration to Talairach space. Results: Children with ADHD had decreased FA in areas that have been implicated in the pathophysiology of ADHD: right premotor, right striatal, right cerebral peduncle, left middle cerebellar peduncle, left cerebellum, and left parieto-occipital areas. Conclusions: These preliminary data support the hypothesis that alterations in brain WM integrity in frontal and cerebellar regions occur in ADHD. The pattern of decreased FA might implicate the corticopontocerebellar circuit in the pathophysiology of ADHD.
AB - Background: The purpose of this study was to explore whether there are white matter (WM) abnormalities in children with attention-deficit/hyperactivity disorder (ADHD) using diffusion tensor imaging. Based upon the literature, we predicted decreased fractional anisotropy (FA) findings in the frontal and cerebellar regions. Methods: Eighteen patients with ADHD and 15 age- and gender-matched healthy volunteers received DTI assessments. Fractional anisotropy maps of WM were compared between groups with a voxelwise analysis after intersubject registration to Talairach space. Results: Children with ADHD had decreased FA in areas that have been implicated in the pathophysiology of ADHD: right premotor, right striatal, right cerebral peduncle, left middle cerebellar peduncle, left cerebellum, and left parieto-occipital areas. Conclusions: These preliminary data support the hypothesis that alterations in brain WM integrity in frontal and cerebellar regions occur in ADHD. The pattern of decreased FA might implicate the corticopontocerebellar circuit in the pathophysiology of ADHD.
KW - Attention-deficit/hyperactivity disorder
KW - Children
KW - Diffusion tensor imaging
KW - White matter
KW - magnetic resonance imaging
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U2 - 10.1016/j.biopsych.2004.11.047
DO - 10.1016/j.biopsych.2004.11.047
M3 - Article
C2 - 15737658
AN - SCOPUS:20044375728
VL - 57
SP - 448
EP - 455
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
IS - 5
ER -