TY - JOUR
T1 - Atypical fetal development
T2 - Fetal alcohol syndrome, nutritional deprivation, teratogens, and risk for neurodevelopmental disorders and psychopathology
AU - Georgieff, Michael K.
AU - Tran, Phu V.
AU - Carlson, Erik S.
N1 - Publisher Copyright:
© Copyright 2018 Cambridge University Press.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action.
AB - Accumulating evidence indicates that the fetal environment plays an important role in brain development and sets the brain on a trajectory across the life span. An abnormal fetal environment results when factors that should be present during a critical period of development are absent or when factors that should not be in the developing brain are present. While these factors may acutely disrupt brain function, the real cost to society resides in the long-term effects, which include important mental health issues. We review the effects of three factors, fetal alcohol exposure, teratogen exposure, and nutrient deficiencies, on the developing brain and the consequent risk for developmental psychopathology. Each is reviewed with respect to the evidence found in epidemiological and clinical studies in humans as well as preclinical molecular and cellular studies that explicate mechanisms of action.
UR - http://www.scopus.com/inward/record.url?scp=85051048638&partnerID=8YFLogxK
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U2 - 10.1017/S0954579418000500
DO - 10.1017/S0954579418000500
M3 - Article
C2 - 30068419
AN - SCOPUS:85051048638
SN - 0954-5794
VL - 30
SP - 1063
EP - 1086
JO - Development and psychopathology
JF - Development and psychopathology
IS - 3
ER -