Numerous studies have implicated frontal lobe dysfunction in anger-related impulsive violent behavior; however, few studies have looked at frontal activity during angry states in violent individuals. Using PET and a script-driven imagery paradigm, we report on autobiographical memories of angry vs. neutral memories in violent patients and psychiatric matched controls. Relative to recall of neutral memories, recall of anger-laden memories was associated with an activation of frontal regions among control subjects but not violent subjects. Violent subjects demonstrated relatively greater activations in the left amygdala, pontine, and cerebellar regions compared to control subjects.
Bibliographical noteFunding Information:
This study was supported by a grant from the Minnesota Medical Foundation awarded to the first author, and was supported with resources and the use of facilities at the Minneapolis VA Medical Center. The views expressed in this paper are those of the authors and do not necessarily reflect those of the Department of Veterans Affairs or the United States government.
- Frontal lobes