Autoimmune neutropenia of infancy and early childhood

Joseph P. Neglia; Jan Watterson; Mary Clay; William Kline; Naomi L.C. Luban; Clark M. Smith; John R. Priest

doi:10.3109/08880019309029518

Autoimmune neutropenia of infancy and early childhood

Joseph P. Neglia, Jan Watterson, Mary Clay, William Kline, Naomi L.C. Luban, Clark M. Smith, John R. Priest

Pediatrics - Hematology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Forty-one children were identified with autoimmune neutropenia of infancy and early childhood (absolute neutrophil count [ANC] less than 500/μ and demonstrable serum antineutrophil antibodies). There were 21 boys and 20 girls; the median age at diagnosis was 11 months (range 5-38 months). No life-threatening infections occurred. There was a gradual upward trend in ANC in all patients over many months, with 87% having an ANC >1000/μl by 24 months from diagnosis. Among various clinical and laboratory parameters analyzed statistically, only younger age at diagnosis was associated with earlier neutrophil recovery. There was no association between degree or duration of neutropenia and sex, race, antibody reactivity, or presence of serious illness at diagnosis.

Original language	English (US)
Pages (from-to)	369-376
Number of pages	8
Journal	Pediatric hematology and oncology
Volume	10
Issue number	4
DOIs	https://doi.org/10.3109/08880019309029518
State	Published - 1993

Bibliographical note

Funding Information:
Funded by Pine Tree Apple Tennis Classic Oncology Research Funds, Grant 5R0 1-H 1-2658-02 from the National Heart, Lung and Blood Institute and research funds from the American National Red Cross and the Children’s Cancer Research Fund of the University of Minnesota. J. P. Neglia is the recipient of the National Cancer Institute Clinical Investigator Award (CA 01240). The authors thank the numerous referring physicians and families from Minnesota, Wisconsin, and the Washington, D.C. area who provided us with information for this study. We also gratefully acknowledge the data collection efforts of Dr. Sylvia Gunawen.

Keywords

Autoimmune
Childhood
Immune-mediated
Neutropenia

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title = "Autoimmune neutropenia of infancy and early childhood",

abstract = "Forty-one children were identified with autoimmune neutropenia of infancy and early childhood (absolute neutrophil count [ANC] less than 500/μ and demonstrable serum antineutrophil antibodies). There were 21 boys and 20 girls; the median age at diagnosis was 11 months (range 5-38 months). No life-threatening infections occurred. There was a gradual upward trend in ANC in all patients over many months, with 87% having an ANC >1000/μl by 24 months from diagnosis. Among various clinical and laboratory parameters analyzed statistically, only younger age at diagnosis was associated with earlier neutrophil recovery. There was no association between degree or duration of neutropenia and sex, race, antibody reactivity, or presence of serious illness at diagnosis.",

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author = "Neglia, {Joseph P.} and Jan Watterson and Mary Clay and William Kline and Luban, {Naomi L.C.} and Smith, {Clark M.} and Priest, {John R.}",

note = "Funding Information: Funded by Pine Tree Apple Tennis Classic Oncology Research Funds, Grant 5R0 1-H 1-2658-02 from the National Heart, Lung and Blood Institute and research funds from the American National Red Cross and the Children{\textquoteright}s Cancer Research Fund of the University of Minnesota. J. P. Neglia is the recipient of the National Cancer Institute Clinical Investigator Award (CA 01240). The authors thank the numerous referring physicians and families from Minnesota, Wisconsin, and the Washington, D.C. area who provided us with information for this study. We also gratefully acknowledge the data collection efforts of Dr. Sylvia Gunawen.",

year = "1993",

doi = "10.3109/08880019309029518",

language = "English (US)",

volume = "10",

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T1 - Autoimmune neutropenia of infancy and early childhood

AU - Neglia, Joseph P.

AU - Watterson, Jan

AU - Clay, Mary

AU - Kline, William

AU - Luban, Naomi L.C.

AU - Smith, Clark M.

AU - Priest, John R.

N1 - Funding Information: Funded by Pine Tree Apple Tennis Classic Oncology Research Funds, Grant 5R0 1-H 1-2658-02 from the National Heart, Lung and Blood Institute and research funds from the American National Red Cross and the Children’s Cancer Research Fund of the University of Minnesota. J. P. Neglia is the recipient of the National Cancer Institute Clinical Investigator Award (CA 01240). The authors thank the numerous referring physicians and families from Minnesota, Wisconsin, and the Washington, D.C. area who provided us with information for this study. We also gratefully acknowledge the data collection efforts of Dr. Sylvia Gunawen.

PY - 1993

Y1 - 1993

N2 - Forty-one children were identified with autoimmune neutropenia of infancy and early childhood (absolute neutrophil count [ANC] less than 500/μ and demonstrable serum antineutrophil antibodies). There were 21 boys and 20 girls; the median age at diagnosis was 11 months (range 5-38 months). No life-threatening infections occurred. There was a gradual upward trend in ANC in all patients over many months, with 87% having an ANC >1000/μl by 24 months from diagnosis. Among various clinical and laboratory parameters analyzed statistically, only younger age at diagnosis was associated with earlier neutrophil recovery. There was no association between degree or duration of neutropenia and sex, race, antibody reactivity, or presence of serious illness at diagnosis.

AB - Forty-one children were identified with autoimmune neutropenia of infancy and early childhood (absolute neutrophil count [ANC] less than 500/μ and demonstrable serum antineutrophil antibodies). There were 21 boys and 20 girls; the median age at diagnosis was 11 months (range 5-38 months). No life-threatening infections occurred. There was a gradual upward trend in ANC in all patients over many months, with 87% having an ANC >1000/μl by 24 months from diagnosis. Among various clinical and laboratory parameters analyzed statistically, only younger age at diagnosis was associated with earlier neutrophil recovery. There was no association between degree or duration of neutropenia and sex, race, antibody reactivity, or presence of serious illness at diagnosis.

KW - Autoimmune

KW - Childhood

KW - Immune-mediated

KW - Neutropenia

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Autoimmune neutropenia of infancy and early childhood

Abstract

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