TY - JOUR
T1 - Autologous hematopoietic stem cell transplant with melphalan and thiotepa is safe and feasible in pediatric patients with low normalized glomerular filtration rate
AU - Termuhlen, Amanda M.
AU - Grovas, Alfred
AU - Klopfenstein, Kathryn
AU - Rosselet, Robin
AU - Gross, Thomas G.
PY - 2006/11
Y1 - 2006/11
N2 - Normalized glomerular filtration rate (nGFR) <60 mL/min/1.73 m 2 often precludes hematopoietic stem cell transplant (HSCT) in pediatric patients. Three patients with nGFR < 60 mL/min/1.73 m2 enrolled on an institutional phase I trial of HSCT preparative therapy for advanced and recurrent solid tumors with escalating melphalan, ranging from 135 to 180 mg/m2, thiotepa (600 mg/m2), and vincristine (2 mg/m2). An additional patient with low nGFR was treated with the same preparative therapy. None of the patients developed acute renal failure, excess toxicities during HSCT or delayed engraftment. These cases demonstrate that it is feasible and safe to perform HSCT in pediatric patients with low nGFR using melphalan- and thiotepa-based preparative therapy.
AB - Normalized glomerular filtration rate (nGFR) <60 mL/min/1.73 m 2 often precludes hematopoietic stem cell transplant (HSCT) in pediatric patients. Three patients with nGFR < 60 mL/min/1.73 m2 enrolled on an institutional phase I trial of HSCT preparative therapy for advanced and recurrent solid tumors with escalating melphalan, ranging from 135 to 180 mg/m2, thiotepa (600 mg/m2), and vincristine (2 mg/m2). An additional patient with low nGFR was treated with the same preparative therapy. None of the patients developed acute renal failure, excess toxicities during HSCT or delayed engraftment. These cases demonstrate that it is feasible and safe to perform HSCT in pediatric patients with low nGFR using melphalan- and thiotepa-based preparative therapy.
KW - Hematopoietic stem cell transplant
KW - Neuroblastoma
KW - Renal complications
KW - Wilms' tumor
UR - http://www.scopus.com/inward/record.url?scp=33749566329&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749566329&partnerID=8YFLogxK
U2 - 10.1111/j.1399-3046.2006.00589.x
DO - 10.1111/j.1399-3046.2006.00589.x
M3 - Article
C2 - 17032431
AN - SCOPUS:33749566329
SN - 1397-3142
VL - 10
SP - 830
EP - 834
JO - Pediatric transplantation
JF - Pediatric transplantation
IS - 7
ER -