Abstract
Functional immunoglobulin gene rearrangement is a sine qua non for successful B cell development in mammalian bone marrow, but other factors are also important. Studies reported during the past year have contributed new insight into the surface receptor complexes and signaling outcomes that influence the fate of B cell precursors. Identification and characterization of secreted and membrane-associated stromal cell products, and their actions on B-cell precursors, was a parallel area of ongoing investigation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 188-195 |
| Number of pages | 8 |
| Journal | Current Opinion in Immunology |
| Volume | 10 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 1998 |
| Externally published | Yes |
Bibliographical note
Funding Information:E-mail discussions with Ted Bertrand and Mark Schlissel are deeply appreciated. I thank Adelia Falk and Julie Pribyl for assistance with the manuscript. Work in my laboratory is supported by National Institutes of Health grants R01-CA31685 and R01-CA76055.