TY - JOUR
T1 - B-cell targeting in chronic graft-versus-host disease
AU - Zeiser, Robert
AU - Sarantopoulos, Stefanie
AU - Blazar, Bruce R
N1 - Publisher Copyright:
© 2018 by The American Society of Hematology.
PY - 2018/3/29
Y1 - 2018/3/29
N2 - Over the last decade, our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.
AB - Over the last decade, our understanding of the pathophysiology of chronic graft-versus-host disease (cGVHD) has improved considerably. In this spotlight, we discuss emerging insights into the pathophysiology of cGVHD with a focus on B cells. First, we summarize supporting evidence derived from mouse and human studies. Next, novel cGVHD therapy approaches that target B cells will be covered to provide treating physicians with an overview of the rationale behind the emerging armamentarium against cGVHD.
UR - http://www.scopus.com/inward/record.url?scp=85047624133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85047624133&partnerID=8YFLogxK
U2 - 10.1182/blood-2017-11-784017
DO - 10.1182/blood-2017-11-784017
M3 - Article
C2 - 29437591
AN - SCOPUS:85047624133
SN - 0006-4971
VL - 131
SP - 1399
EP - 1405
JO - Blood
JF - Blood
IS - 13
ER -