TY - JOUR
T1 - Bcl-2-family proteins
T2 - The role of the BH3 domain in apoptosis
AU - Kelekar, Ameeta
AU - Thompson, Craig B.
PY - 1998/8/1
Y1 - 1998/8/1
N2 - Bcl-2-related proteins have come to occupy a prominent position in the realm of progmmmed cell death. Members of this fast-growing family are highly related in one or more specific regions, commonly referred to as Bcl-2 homology (BH) domains. BH domains contribute at multiple levels to the function of these proteins in cell death and survival. Particularly intriguing is the emergence of the BH3 domain as a potent 'death domain' and of a growing subclass of pro-apoptotic proteins with no similarity to Bcl-2 beyond their BH3 homology. Here, the authors classify proteins of the Bcl-2 family on the basis of function and domain organization, discuss the importance of the BH3 domain in protein-protein interactions and in cell death and provide possible explanations for the perceived redundancy in the expression of this subclass of death promoters.
AB - Bcl-2-related proteins have come to occupy a prominent position in the realm of progmmmed cell death. Members of this fast-growing family are highly related in one or more specific regions, commonly referred to as Bcl-2 homology (BH) domains. BH domains contribute at multiple levels to the function of these proteins in cell death and survival. Particularly intriguing is the emergence of the BH3 domain as a potent 'death domain' and of a growing subclass of pro-apoptotic proteins with no similarity to Bcl-2 beyond their BH3 homology. Here, the authors classify proteins of the Bcl-2 family on the basis of function and domain organization, discuss the importance of the BH3 domain in protein-protein interactions and in cell death and provide possible explanations for the perceived redundancy in the expression of this subclass of death promoters.
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U2 - 10.1016/S0962-8924(98)01321-X
DO - 10.1016/S0962-8924(98)01321-X
M3 - Review article
C2 - 9704409
AN - SCOPUS:0032146987
SN - 0962-8924
VL - 8
SP - 324
EP - 330
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 8
ER -