BCoR, a novel corepressor involved in BCL-6 repression

Khanh D. Huynh, Wolfgang Fischle, Eric Verdin, Vivian J. Bardwell

Research output: Contribution to journalArticlepeer-review

305 Scopus citations

Abstract

BCL-6 encodes a POZ/zinc finger transcriptional repressor that is required for germinal center formation and may influence apoptosis. Aberrant expression of BCL-6 due to chromosomal translocations is implicated in certain subtypes of non-Hodgkin's lymphoma. The POZ domains of BCL-6 and several other POZ proteins interact with corepressors N-CoR and SMRT. Here we identify and characterize a novel corepressor BCoR (BCL-6 interacting corepressor), which is expressed ubiquitously in human tissues. BCoR can function as a corepressor when tethered to DNA and, when overexpressed, can potentiate BCL-6 repression. Specific class I and II histone deacetylases (HDACs) interact in vivo with BCoR, suggesting that BCoR may functionally link these two classes of HDACs. Strikingly, BCoR interacts selectively with the POZ domain of BCL-6 but not with eight other POZ proteins tested, including PLZF. Additionally, interactions between the BCL-6 POZ domain and SMRT, N-CoR, and BCoR are mutually exclusive. The specificity of the BCL- 6/BCoR interaction suggests that BCoR may have a role in BCL-6-associated lymphomas.

Original languageEnglish (US)
Pages (from-to)1810-1823
Number of pages14
JournalGenes and Development
Volume14
Issue number14
StatePublished - Jul 15 2000

Keywords

  • BCL-6
  • BTB
  • HDAC
  • POZ
  • Transcriptional repression

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