Behavioral–genetic associations in the Human Connectome Project

Peka Christova; Jasmine Joseph; Apostolos P. Georgopoulos

doi:10.1007/s00221-020-05893-w

Behavioral–genetic associations in the Human Connectome Project

Peka Christova, Jasmine Joseph, Apostolos P. Georgopoulos

Neuroscience

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The Human Connectome Project (HCP) provides a rich dataset of quantitative and domain-specific behavioral measures from twins and extensive family structures. This makes the dataset a unique and a valuable resource to investigate heritability and determine individual differences. Using a set of measures of behavioral domains (motor, emotion, personality, sensory, and cognition), we estimated the intraclass correlations (ICCs) and heritability of 56 behavioral measures for 4 genetically identified groups of participants: monozygotic (MZ) twins, dizygotic (DZ) twins, non-twin siblings (SB), and unrelated individuals (NR). The ICCs range varied among behavioral domains but systematically so among the four genetic groups. We found the same rank order of ICCs, from the highest values for MZ twins, statistically significantly smaller for the DZ twins and sibling group (compared to MZ), and close to zero for NR. The mean heritability values of the five behavioral domains were: cognition h² = 0.405, emotion h² = 0.316, motor h² = 0.138, personality h² = 0.444, and sensory h² = 0.193. These domains share overlapping brain networks. The heritability of motor domain was significantly smaller than cognitive, personality, and emotion domains. These findings provide new insight into the effect of genetics on the various diverse behavioral measures.

Original language	English (US)
Pages (from-to)	2445-2456
Number of pages	12
Journal	Experimental Brain Research
Volume	238
Issue number	11
DOIs	https://doi.org/10.1007/s00221-020-05893-w
State	Published - Nov 1 2020

Bibliographical note

Funding Information:
Data were provided by the Human Connectome Project, WU-Minn Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil; 1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University.

Publisher Copyright:
© 2020, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

Keywords

Behavioral domains
Heritability
Non-twin siblings
Twins

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Behavioral–genetic associations in the Human Connectome Project

Abstract

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Keywords

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