Behavioural deficits associated with maternal immune activation in the rat model of schizophrenia

Amy R. Wolff, Kirsten R. Cheyne, David K. Bilkey

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function.

Original languageEnglish (US)
Pages (from-to)382-387
Number of pages6
JournalBehavioural Brain Research
Volume225
Issue number1
DOIs
StatePublished - Nov 20 2011
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported by a grant from the Health Research Council of New Zealand . We would also like to thank Saralee Illingworth for her involvement.

Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.

Keywords

  • Context
  • Immune
  • Memory
  • Rat
  • Reversal
  • Schizophrenia

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