Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

John J Marini; John R. Hotchkiss; Alain F Broccard

doi:10.1186/cc2392

Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

John J Marini, John R. Hotchkiss, Alain F Broccard

Research output: Contribution to journal › Review article › peer-review

79 Scopus citations

Abstract

Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.

Original language	English (US)
Pages (from-to)	435-444
Number of pages	10
Journal	Critical Care
Volume	7
Issue number	6
DOIs	https://doi.org/10.1186/cc2392
State	Published - Dec 2003

Keywords

Acute respiratory distress syndrome
Capillary stress fracture
Mechanical ventilation
Vascular injury
Ventilator-induced lung injury

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abstract = "Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.",

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AU - Broccard, Alain F

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AB - Experimental and clinical evidence point strongly toward the potential for microvascular stresses to influence the severity and expression of ventilator associated lung injury. Intense microvascular stresses not only influence edema but predispose to structural failure of the gas-blood barrier, possibly with adverse consequences for the lung and for extrapulmonary organs. Taking measures to lower vascular stress may offer a logical, but as yet unproven, extension of a lung-protective strategy for life support in ARDS.

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KW - Capillary stress fracture

KW - Mechanical ventilation

KW - Vascular injury

KW - Ventilator-induced lung injury

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Bench-to-bedside review: Microvascular and airspace linkage in ventilator-induced lung injury

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